Targeted DNA Methylation by a DNA Methyltransferase Coupled to a Triple Helix Forming Oligonucleotide To Down-Regulate the Epithelial Cell Adhesion Molecule

The epithelial cell adhesion molecule (EpCAM) is a membrane glycoprotein that has been identified as a marker of cancer-initiating cells. EpCAM is highly expressed on most carcinomas, and transient silencing of EpCAM expression leads to reduced oncogenic potential. To silence the EpCAM gene in a per...

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Detalles Bibliográficos
Autores principales: van der Gun, Bernardina T. F., Maluszynska-Hoffman, Maria, Kiss, Antal, Arendzen, Alice J., Ruiters, Marcel H. J., McLaughlin, Pamela M. J., Weinhold, Elmar, Rots, Marianne G.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907751/
https://www.ncbi.nlm.nih.gov/pubmed/20593890
http://dx.doi.org/10.1021/bc1000388

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