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Controlling the Mdm2-Mdmx-p53 Circuit

The p53 tumor suppressor is a key protein in maintaining the integrity of the genome by inducing either cell cycle arrest or apoptosis following cellular stress signals. Two human family members, Mdm2 and Mdmx, are primarily responsible for inactivating p53 transcription and targeting p53 protein fo...

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Detalles Bibliográficos
Autores principales:	Waning, David L., Lehman, Jason A., Batuello, Christopher N., Mayo, Lindsey D.
Formato:	Texto
Lenguaje:	English
Publicado:	MDPI 2010
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907906/ https://www.ncbi.nlm.nih.gov/pubmed/20651945 http://dx.doi.org/10.3390/ph3051576

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