Targeting TOR dependence in cancer

A challenge in cancer therapy has been to identify targets whose function is essential for survival of malignant cells but not normal cells. This Perspective discusses recent evidence that novel inhibitors of the kinase TOR can provide an unprecedented balance of anti-cancer efficacy and tolerabilit...

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Detalles Bibliográficos
Autores principales: Janes, Matthew R., Fruman, David A.
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908250/
https://www.ncbi.nlm.nih.gov/pubmed/20657741
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author Janes, Matthew R.
Fruman, David A.
author_facet Janes, Matthew R.
Fruman, David A.
author_sort Janes, Matthew R.
collection PubMed
description A challenge in cancer therapy has been to identify targets whose function is essential for survival of malignant cells but not normal cells. This Perspective discusses recent evidence that novel inhibitors of the kinase TOR can provide an unprecedented balance of anti-cancer efficacy and tolerability.
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spelling pubmed-29082502010-07-22 Targeting TOR dependence in cancer Janes, Matthew R. Fruman, David A. Oncotarget Research Perspective A challenge in cancer therapy has been to identify targets whose function is essential for survival of malignant cells but not normal cells. This Perspective discusses recent evidence that novel inhibitors of the kinase TOR can provide an unprecedented balance of anti-cancer efficacy and tolerability. Impact Journals LLC 2010-05-10 /pmc/articles/PMC2908250/ /pubmed/20657741 Text en Copyright: © 2010 Janes and Fruman http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Perspective
Janes, Matthew R.
Fruman, David A.
Targeting TOR dependence in cancer
title Targeting TOR dependence in cancer
title_full Targeting TOR dependence in cancer
title_fullStr Targeting TOR dependence in cancer
title_full_unstemmed Targeting TOR dependence in cancer
title_short Targeting TOR dependence in cancer
title_sort targeting tor dependence in cancer
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908250/
https://www.ncbi.nlm.nih.gov/pubmed/20657741
work_keys_str_mv AT janesmatthewr targetingtordependenceincancer
AT frumandavida targetingtordependenceincancer

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