Mapping of the Mouse Actin Capping Protein Beta Subunit Gene

BACKGROUND: Capping protein (CP), a heterodimer of α and β subunits, is found in all eukaryotes. CP binds to the barbed ends of actin filaments in vitro and controls actin assembly and cell motility in vivo. Vertebrates have three isoforms of CPβ produced by alternatively splicing from one gene; low...

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Detalles Bibliográficos
Autores principales: Hart, Marilyn C, Korshunova, Yulia O, Cooper, John A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2000
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29085/
https://www.ncbi.nlm.nih.gov/pubmed/11001587
http://dx.doi.org/10.1186/1471-2164-1-1
Descripción
Sumario:BACKGROUND: Capping protein (CP), a heterodimer of α and β subunits, is found in all eukaryotes. CP binds to the barbed ends of actin filaments in vitro and controls actin assembly and cell motility in vivo. Vertebrates have three isoforms of CPβ produced by alternatively splicing from one gene; lower organisms have one gene and one isoform. RESULTS: We isolated genomic clones corresponding to the β subunit of mouse CP and identified its chromosomal location by interspecies backcross mapping. CONCLUSIONS: The CPβ gene (Cappb1) mapped to Chromosome 4 between Cdc42 and D4Mit312. Three mouse mutations, snubnose, curly tail, and cribriform degeneration, map in the vicinity of the β gene.

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