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Co-Depletion of Cathepsin B and uPAR Induces G0/G1 Arrest in Glioma via FOXO3a Mediated p27(Kip1) Upregulation

BACKGROUND: Cathepsin B and urokinase plasminogen activator receptor (uPAR) are both known to be overexpressed in gliomas. Our previous work and that of others strongly suggest a relationship between the infiltrative phenotype of glioma and the expression of cathepsin B and uPAR. Though their role i...

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Detalles Bibliográficos
Autores principales:	Gopinath, Sreelatha, Malla, Rama Rao, Gondi, Christopher S., Alapati, Kiranmai, Fassett, Daniel, Klopfenstein, Jeffrey D., Dinh, Dzung H., Gujrati, Meena, Rao, Jasti S.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908539/ https://www.ncbi.nlm.nih.gov/pubmed/20661471 http://dx.doi.org/10.1371/journal.pone.0011668

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