Cargando…

Geographical origin of Plasmodium vivax in the Republic of Korea: haplotype network analysis based on the parasite's mitochondrial genome

BACKGROUND: The Republic of Korea (South Korea) is one of the countries where vivax malaria had been successfully eradicated by the late 1970s. However, re-emergence of vivax malaria in South Korea was reported in 1993. Several epidemiological studies and some genetic studies using antigenic molecul...

Descripción completa

Detalles Bibliográficos
Autores principales: Iwagami, Moritoshi, Hwang, Seung-Young, Fukumoto, Megumi, Hayakawa, Toshiyuki, Tanabe, Kazuyuki, Kim, So-Hee, Kho, Weon-Gyu, Kano, Shigeyuki
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908639/
https://www.ncbi.nlm.nih.gov/pubmed/20576165
http://dx.doi.org/10.1186/1475-2875-9-184
_version_ 1782184210632540160
author Iwagami, Moritoshi
Hwang, Seung-Young
Fukumoto, Megumi
Hayakawa, Toshiyuki
Tanabe, Kazuyuki
Kim, So-Hee
Kho, Weon-Gyu
Kano, Shigeyuki
author_facet Iwagami, Moritoshi
Hwang, Seung-Young
Fukumoto, Megumi
Hayakawa, Toshiyuki
Tanabe, Kazuyuki
Kim, So-Hee
Kho, Weon-Gyu
Kano, Shigeyuki
author_sort Iwagami, Moritoshi
collection PubMed
description BACKGROUND: The Republic of Korea (South Korea) is one of the countries where vivax malaria had been successfully eradicated by the late 1970s. However, re-emergence of vivax malaria in South Korea was reported in 1993. Several epidemiological studies and some genetic studies using antigenic molecules of Plasmodium vivax in the country have been reported, but the evolutionary history of P. vivax has not been fully understood. In this study, the origin of the South Korean P. vivax population was estimated by molecular phylogeographic analysis. METHODS: A haplotype network analysis based on P. vivax mitochondrial (mt) DNA sequences was conducted on 11 P. vivax isolates from South Korea and another 282 P. vivax isolates collected worldwide. RESULTS: The network analysis of P. vivax mtDNA sequences showed that the coexistence of two different groups (A and B) in South Korea. Groups A and B were identical or close to two different populations in southern China. CONCLUSIONS: Although the direct introduction of the two P. vivax populations in South Korea were thought to have been from North Korea, the results of this analysis suggest the genealogical origin to be the two different populations in southern China.
format Text
id pubmed-2908639
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-29086392010-07-23 Geographical origin of Plasmodium vivax in the Republic of Korea: haplotype network analysis based on the parasite's mitochondrial genome Iwagami, Moritoshi Hwang, Seung-Young Fukumoto, Megumi Hayakawa, Toshiyuki Tanabe, Kazuyuki Kim, So-Hee Kho, Weon-Gyu Kano, Shigeyuki Malar J Research BACKGROUND: The Republic of Korea (South Korea) is one of the countries where vivax malaria had been successfully eradicated by the late 1970s. However, re-emergence of vivax malaria in South Korea was reported in 1993. Several epidemiological studies and some genetic studies using antigenic molecules of Plasmodium vivax in the country have been reported, but the evolutionary history of P. vivax has not been fully understood. In this study, the origin of the South Korean P. vivax population was estimated by molecular phylogeographic analysis. METHODS: A haplotype network analysis based on P. vivax mitochondrial (mt) DNA sequences was conducted on 11 P. vivax isolates from South Korea and another 282 P. vivax isolates collected worldwide. RESULTS: The network analysis of P. vivax mtDNA sequences showed that the coexistence of two different groups (A and B) in South Korea. Groups A and B were identical or close to two different populations in southern China. CONCLUSIONS: Although the direct introduction of the two P. vivax populations in South Korea were thought to have been from North Korea, the results of this analysis suggest the genealogical origin to be the two different populations in southern China. BioMed Central 2010-06-25 /pmc/articles/PMC2908639/ /pubmed/20576165 http://dx.doi.org/10.1186/1475-2875-9-184 Text en Copyright ©2010 Iwagami et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Iwagami, Moritoshi
Hwang, Seung-Young
Fukumoto, Megumi
Hayakawa, Toshiyuki
Tanabe, Kazuyuki
Kim, So-Hee
Kho, Weon-Gyu
Kano, Shigeyuki
Geographical origin of Plasmodium vivax in the Republic of Korea: haplotype network analysis based on the parasite's mitochondrial genome
title Geographical origin of Plasmodium vivax in the Republic of Korea: haplotype network analysis based on the parasite's mitochondrial genome
title_full Geographical origin of Plasmodium vivax in the Republic of Korea: haplotype network analysis based on the parasite's mitochondrial genome
title_fullStr Geographical origin of Plasmodium vivax in the Republic of Korea: haplotype network analysis based on the parasite's mitochondrial genome
title_full_unstemmed Geographical origin of Plasmodium vivax in the Republic of Korea: haplotype network analysis based on the parasite's mitochondrial genome
title_short Geographical origin of Plasmodium vivax in the Republic of Korea: haplotype network analysis based on the parasite's mitochondrial genome
title_sort geographical origin of plasmodium vivax in the republic of korea: haplotype network analysis based on the parasite's mitochondrial genome
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908639/
https://www.ncbi.nlm.nih.gov/pubmed/20576165
http://dx.doi.org/10.1186/1475-2875-9-184
work_keys_str_mv AT iwagamimoritoshi geographicaloriginofplasmodiumvivaxintherepublicofkoreahaplotypenetworkanalysisbasedontheparasitesmitochondrialgenome
AT hwangseungyoung geographicaloriginofplasmodiumvivaxintherepublicofkoreahaplotypenetworkanalysisbasedontheparasitesmitochondrialgenome
AT fukumotomegumi geographicaloriginofplasmodiumvivaxintherepublicofkoreahaplotypenetworkanalysisbasedontheparasitesmitochondrialgenome
AT hayakawatoshiyuki geographicaloriginofplasmodiumvivaxintherepublicofkoreahaplotypenetworkanalysisbasedontheparasitesmitochondrialgenome
AT tanabekazuyuki geographicaloriginofplasmodiumvivaxintherepublicofkoreahaplotypenetworkanalysisbasedontheparasitesmitochondrialgenome
AT kimsohee geographicaloriginofplasmodiumvivaxintherepublicofkoreahaplotypenetworkanalysisbasedontheparasitesmitochondrialgenome
AT khoweongyu geographicaloriginofplasmodiumvivaxintherepublicofkoreahaplotypenetworkanalysisbasedontheparasitesmitochondrialgenome
AT kanoshigeyuki geographicaloriginofplasmodiumvivaxintherepublicofkoreahaplotypenetworkanalysisbasedontheparasitesmitochondrialgenome