Ancestry-Shift Refinement Mapping of the C6orf97-ESR1 Breast Cancer Susceptibility Locus

We used an approach that we term ancestry-shift refinement mapping to investigate an association, originally discovered in a GWAS of a Chinese population, between rs2046210[T] and breast cancer susceptibility. The locus is on 6q25.1 in proximity to the C6orf97 and estrogen receptor α (ESR1) genes. W...

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Autores principales: Stacey, Simon N., Sulem, Patrick, Zanon, Carlo, Gudjonsson, Sigurjon A., Thorleifsson, Gudmar, Helgason, Agnar, Jonasdottir, Aslaug, Besenbacher, Soren, Kostic, Jelena P., Fackenthal, James D., Huo, Dezheng, Adebamowo, Clement, Ogundiran, Temidayo, Olson, Janet E., Fredericksen, Zachary S., Wang, Xianshu, Look, Maxime P., Sieuwerts, Anieta M., Martens, John W. M., Pajares, Isabel, Garcia-Prats, Maria D., Ramon-Cajal, Jose M., de Juan, Ana, Panadero, Angeles, Ortega, Eugenia, Aben, Katja K. H., Vermeulen, Sita H., Asadzadeh, Fatemeh, van Engelenburg, K. C. Anton, Margolin, Sara, Shen, Chen-Yang, Wu, Pei-Ei, Försti, Asta, Lenner, Per, Henriksson, Roger, Johansson, Robert, Enquist, Kerstin, Hallmans, Göran, Jonsson, Thorvaldur, Sigurdsson, Helgi, Alexiusdottir, Kristin, Gudmundsson, Julius, Sigurdsson, Asgeir, Frigge, Michael L., Gudmundsson, Larus, Kristjansson, Kristleifur, Halldorsson, Bjarni V., Styrkarsdottir, Unnur, Gulcher, Jeffrey R., Hemminki, Kari, Lindblom, Annika, Kiemeney, Lambertus A., Mayordomo, Jose I., Foekens, John A., Couch, Fergus J., Olopade, Olufunmilayo I., Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Rafnar, Thorunn, Johannsson, Oskar T., Stefansson, Kari
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908678/
https://www.ncbi.nlm.nih.gov/pubmed/20661439
http://dx.doi.org/10.1371/journal.pgen.1001029

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