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Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis
The structural basis of the antifracture efficacy of strontium ranelate and alendronate is incompletely understood. We compared the effects of strontium ranelate and alendronate on distal tibia microstructure over 2 years using HR-pQCT. In this pre-planned, interim, intention-to-treat analysis at 12...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Springer-Verlag
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908746/ https://www.ncbi.nlm.nih.gov/pubmed/20512336 http://dx.doi.org/10.1007/s00296-010-1542-y |
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author | Rizzoli, René Laroche, Michel Krieg, Marc-Antoine Frieling, Isolde Thomas, Thierry Delmas, Pierre Felsenberg, Dieter |
author_facet | Rizzoli, René Laroche, Michel Krieg, Marc-Antoine Frieling, Isolde Thomas, Thierry Delmas, Pierre Felsenberg, Dieter |
author_sort | Rizzoli, René |
collection | PubMed |
description | The structural basis of the antifracture efficacy of strontium ranelate and alendronate is incompletely understood. We compared the effects of strontium ranelate and alendronate on distal tibia microstructure over 2 years using HR-pQCT. In this pre-planned, interim, intention-to-treat analysis at 12 months, 88 osteoporotic postmenopausal women (mean age 63.7 ± 7.4) were randomized to strontium ranelate 2 g/day or alendronate 70 mg/week in a double-placebo design. Primary endpoints were changes in microstructure. Secondary endpoints included lumbar and hip areal bone mineral density (aBMD), and bone turnover markers. This trial is registered with http://www.controlled-trials.com, number ISRCTN82719233. Baseline characteristics of the two groups were similar. Treatment with strontium ranelate was associated with increases in mean cortical thickness (CTh, 5.3%), cortical area (4.9%) and trabecular density (2.1%) (all P < 0.001, except cortical area P = 0.013). No significant changes were observed with alendronate. Between-group differences in favor of strontium ranelate were observed for CTh, cortical area, BV/TV and trabecular density (P = 0.045, 0.041, 0.048 and 0.035, respectively). aBMD increased to a similar extent with strontium ranelate and alendronate at the spine (5.7% versus 5.1%, respectively) and total hip (3.3% versus 2.2%, respectively). No significant changes were observed in remodeling markers with strontium ranelate, while suppression was observed with alendronate. Within the methodological constraints of HR-pQCT through its possible sensitivity to X-ray attenuation of different minerals, strontium ranelate had greater effects than alendronate on distal tibia cortical thickness and trabecular volumetric density. |
format | Text |
id | pubmed-2908746 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-29087462010-08-06 Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis Rizzoli, René Laroche, Michel Krieg, Marc-Antoine Frieling, Isolde Thomas, Thierry Delmas, Pierre Felsenberg, Dieter Rheumatol Int Original Article The structural basis of the antifracture efficacy of strontium ranelate and alendronate is incompletely understood. We compared the effects of strontium ranelate and alendronate on distal tibia microstructure over 2 years using HR-pQCT. In this pre-planned, interim, intention-to-treat analysis at 12 months, 88 osteoporotic postmenopausal women (mean age 63.7 ± 7.4) were randomized to strontium ranelate 2 g/day or alendronate 70 mg/week in a double-placebo design. Primary endpoints were changes in microstructure. Secondary endpoints included lumbar and hip areal bone mineral density (aBMD), and bone turnover markers. This trial is registered with http://www.controlled-trials.com, number ISRCTN82719233. Baseline characteristics of the two groups were similar. Treatment with strontium ranelate was associated with increases in mean cortical thickness (CTh, 5.3%), cortical area (4.9%) and trabecular density (2.1%) (all P < 0.001, except cortical area P = 0.013). No significant changes were observed with alendronate. Between-group differences in favor of strontium ranelate were observed for CTh, cortical area, BV/TV and trabecular density (P = 0.045, 0.041, 0.048 and 0.035, respectively). aBMD increased to a similar extent with strontium ranelate and alendronate at the spine (5.7% versus 5.1%, respectively) and total hip (3.3% versus 2.2%, respectively). No significant changes were observed in remodeling markers with strontium ranelate, while suppression was observed with alendronate. Within the methodological constraints of HR-pQCT through its possible sensitivity to X-ray attenuation of different minerals, strontium ranelate had greater effects than alendronate on distal tibia cortical thickness and trabecular volumetric density. Springer-Verlag 2010-05-29 2010 /pmc/articles/PMC2908746/ /pubmed/20512336 http://dx.doi.org/10.1007/s00296-010-1542-y Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Original Article Rizzoli, René Laroche, Michel Krieg, Marc-Antoine Frieling, Isolde Thomas, Thierry Delmas, Pierre Felsenberg, Dieter Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis |
title | Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis |
title_full | Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis |
title_fullStr | Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis |
title_full_unstemmed | Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis |
title_short | Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis |
title_sort | strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908746/ https://www.ncbi.nlm.nih.gov/pubmed/20512336 http://dx.doi.org/10.1007/s00296-010-1542-y |
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