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Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

BACKGROUND: Chronic inflammation of the arterial wall is a key element in the pathogenesis of atherosclerosis, yet the factors that trigger and sustain the inflammation remain elusive. Inflammasomes are cytoplasmic caspase-1-activating protein complexes that promote maturation and secretion of the p...

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Detalles Bibliográficos
Autores principales:	Rajamäki, Kristiina, Lappalainen, Jani, Öörni, Katariina, Välimäki, Elina, Matikainen, Sampsa, Kovanen, Petri T., Eklund, Kari K.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909263/ https://www.ncbi.nlm.nih.gov/pubmed/20668705 http://dx.doi.org/10.1371/journal.pone.0011765

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