SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kγ Activity through Deacetylation of Specific Lysine Residues in Mammals

BACKGROUND: SIRT1, a NAD-dependent deacetylase, has diverse roles in a variety of organs such as regulation of endocrine function and metabolism. However, it remains to be addressed how it regulates hormone release there. METHODOLOGY/PRINCIPAL FINDINGS: Here, we report that SIRT1 is abundantly expre...

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Detalles Bibliográficos
Autores principales: Akieda-Asai, Sayaka, Zaima, Nobuhiro, Ikegami, Koji, Kahyo, Tomoaki, Yao, Ikuko, Hatanaka, Takahiro, Iemura, Shun-ichiro, Sugiyama, Rika, Yokozeki, Takeaki, Eishi, Yoshinobu, Koike, Morio, Ikeda, Kyoji, Chiba, Takuya, Yamaza, Haruyoshi, Shimokawa, Isao, Song, Si-Young, Matsuno, Akira, Mizutani, Akiko, Sawabe, Motoji, Chao, Moses V., Tanaka, Masashi, Kanaho, Yasunori, Natsume, Tohru, Sugimura, Haruhiko, Date, Yukari, McBurney, Michael W., Guarente, Leonard, Setou, Mitsutoshi
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909264/
https://www.ncbi.nlm.nih.gov/pubmed/20668706
http://dx.doi.org/10.1371/journal.pone.0011755

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