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Identification and Characterization of a New Bocavirus Species in Gorillas
A novel parvovirus, provisionally named Gorilla Bocavirus species 1 (GBoV1), was identified in four stool samples from Western gorillas (Gorilla gorilla) with acute enteritis. The complete genomic sequence of the new parvovirus revealed three open reading frames (ORFs) with an organization similar t...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909267/ https://www.ncbi.nlm.nih.gov/pubmed/20668709 http://dx.doi.org/10.1371/journal.pone.0011948 |
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author | Kapoor, Amit Mehta, Natasha Esper, Frank Poljsak-Prijatelj, Mateja Quan, Phenix-Lan Qaisar, Natasha Delwart, Eric Lipkin, W. Ian |
author_facet | Kapoor, Amit Mehta, Natasha Esper, Frank Poljsak-Prijatelj, Mateja Quan, Phenix-Lan Qaisar, Natasha Delwart, Eric Lipkin, W. Ian |
author_sort | Kapoor, Amit |
collection | PubMed |
description | A novel parvovirus, provisionally named Gorilla Bocavirus species 1 (GBoV1), was identified in four stool samples from Western gorillas (Gorilla gorilla) with acute enteritis. The complete genomic sequence of the new parvovirus revealed three open reading frames (ORFs) with an organization similar to that of known bocaviruses. Phylogenetic analysis using complete capsid and non structural (NS) gene sequence suggested that the new parvovirus is most closely related to human bocaviruses (HBoV). However, the NS ORF is more similar in length to the NS ORF found in canine minute virus and bovine parvovirus than in HBoV. Comparative genetic analysis using GBoV and HBoV genomes enabled characterization of unique splice donor and acceptor sites that appear to be highly conserved among all four HBoV species, and provided evidence for expression of two different NS proteins in all primate bocaviruses. GBoV is the first non-human primate bocavirus identified and provides new insights into the genetic diversity and evolution of this highly prevalent and recently discovered group of parvoviruses. |
format | Text |
id | pubmed-2909267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-29092672010-07-28 Identification and Characterization of a New Bocavirus Species in Gorillas Kapoor, Amit Mehta, Natasha Esper, Frank Poljsak-Prijatelj, Mateja Quan, Phenix-Lan Qaisar, Natasha Delwart, Eric Lipkin, W. Ian PLoS One Research Article A novel parvovirus, provisionally named Gorilla Bocavirus species 1 (GBoV1), was identified in four stool samples from Western gorillas (Gorilla gorilla) with acute enteritis. The complete genomic sequence of the new parvovirus revealed three open reading frames (ORFs) with an organization similar to that of known bocaviruses. Phylogenetic analysis using complete capsid and non structural (NS) gene sequence suggested that the new parvovirus is most closely related to human bocaviruses (HBoV). However, the NS ORF is more similar in length to the NS ORF found in canine minute virus and bovine parvovirus than in HBoV. Comparative genetic analysis using GBoV and HBoV genomes enabled characterization of unique splice donor and acceptor sites that appear to be highly conserved among all four HBoV species, and provided evidence for expression of two different NS proteins in all primate bocaviruses. GBoV is the first non-human primate bocavirus identified and provides new insights into the genetic diversity and evolution of this highly prevalent and recently discovered group of parvoviruses. Public Library of Science 2010-07-23 /pmc/articles/PMC2909267/ /pubmed/20668709 http://dx.doi.org/10.1371/journal.pone.0011948 Text en Kapoor et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Kapoor, Amit Mehta, Natasha Esper, Frank Poljsak-Prijatelj, Mateja Quan, Phenix-Lan Qaisar, Natasha Delwart, Eric Lipkin, W. Ian Identification and Characterization of a New Bocavirus Species in Gorillas |
title | Identification and Characterization of a New Bocavirus Species in Gorillas |
title_full | Identification and Characterization of a New Bocavirus Species in Gorillas |
title_fullStr | Identification and Characterization of a New Bocavirus Species in Gorillas |
title_full_unstemmed | Identification and Characterization of a New Bocavirus Species in Gorillas |
title_short | Identification and Characterization of a New Bocavirus Species in Gorillas |
title_sort | identification and characterization of a new bocavirus species in gorillas |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909267/ https://www.ncbi.nlm.nih.gov/pubmed/20668709 http://dx.doi.org/10.1371/journal.pone.0011948 |
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