The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates

Conjugates of purine and pyrimidine nucleosides: thymidine and 2′-deoxyguanosine with cobalt-metallacarborane were studied for their sodium ion complexing properties. Formation of stable complexes of 1 : 1 stoichiometry was proved by ESI MS spectroscopy and (23)Na NMR. Equilibrium constants and ener...

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Autores principales: Olejniczak, Agnieszka B., Milecki, Jan, Schroeder, Grzegorz
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909723/
https://www.ncbi.nlm.nih.gov/pubmed/20671972
http://dx.doi.org/10.1155/2010/196064
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author Olejniczak, Agnieszka B.
Milecki, Jan
Schroeder, Grzegorz
author_facet Olejniczak, Agnieszka B.
Milecki, Jan
Schroeder, Grzegorz
author_sort Olejniczak, Agnieszka B.
collection PubMed
description Conjugates of purine and pyrimidine nucleosides: thymidine and 2′-deoxyguanosine with cobalt-metallacarborane were studied for their sodium ion complexing properties. Formation of stable complexes of 1 : 1 stoichiometry was proved by ESI MS spectroscopy and (23)Na NMR. Equilibrium constants and energies of complex formation were calculated. Complexation of alkali-metals by nucleoside-metallacarborane conjugates may affect the physicochemical and biological properties of the conjugates and should be taken into consideration during biological evaluation of these types of modifications.
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spelling pubmed-29097232010-07-29 The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates Olejniczak, Agnieszka B. Milecki, Jan Schroeder, Grzegorz Bioinorg Chem Appl Research Article Conjugates of purine and pyrimidine nucleosides: thymidine and 2′-deoxyguanosine with cobalt-metallacarborane were studied for their sodium ion complexing properties. Formation of stable complexes of 1 : 1 stoichiometry was proved by ESI MS spectroscopy and (23)Na NMR. Equilibrium constants and energies of complex formation were calculated. Complexation of alkali-metals by nucleoside-metallacarborane conjugates may affect the physicochemical and biological properties of the conjugates and should be taken into consideration during biological evaluation of these types of modifications. Hindawi Publishing Corporation 2010 2010-07-01 /pmc/articles/PMC2909723/ /pubmed/20671972 http://dx.doi.org/10.1155/2010/196064 Text en Copyright © 2010 Agnieszka B. Olejniczak et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Olejniczak, Agnieszka B.
Milecki, Jan
Schroeder, Grzegorz
The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates
title The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates
title_full The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates
title_fullStr The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates
title_full_unstemmed The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates
title_short The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates
title_sort effect of stereochemistry on sodium ion complexation in nucleoside-metallacarborane conjugates
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909723/
https://www.ncbi.nlm.nih.gov/pubmed/20671972
http://dx.doi.org/10.1155/2010/196064
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