Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO(2)(mpETSC)] and [Pt(mpETSC)Cl]

New complexes of dioxovanadium(V), zinc(II), ruthenium(II), palladium(II), and platinum(II) with 6-methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone (HmpETSC) have been synthesized. The composition of these complexes is discussed on the basis of elemental analyses, IR, Raman, NMR ((1)H, (13)...

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Autores principales: Elsayed, Shadia A., El-Hendawy, Ahmed M., Mostafa, Sahar I., Jean-Claude, Bertrand J., Todorova, Margarita, Butler, Ian S.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909729/
https://www.ncbi.nlm.nih.gov/pubmed/20671978
http://dx.doi.org/10.1155/2010/149149
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author Elsayed, Shadia A.
El-Hendawy, Ahmed M.
Mostafa, Sahar I.
Jean-Claude, Bertrand J.
Todorova, Margarita
Butler, Ian S.
author_facet Elsayed, Shadia A.
El-Hendawy, Ahmed M.
Mostafa, Sahar I.
Jean-Claude, Bertrand J.
Todorova, Margarita
Butler, Ian S.
author_sort Elsayed, Shadia A.
collection PubMed
description New complexes of dioxovanadium(V), zinc(II), ruthenium(II), palladium(II), and platinum(II) with 6-methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone (HmpETSC) have been synthesized. The composition of these complexes is discussed on the basis of elemental analyses, IR, Raman, NMR ((1)H, (13)C, and (31)P), and electronic spectral data. The X-ray crystal structures of [VO(2)(mpETSC)] and [Pt(mpETSC)Cl] are also reported. The HmpETSC and its [Zn(HmpETSC)Cl(2)] and [Pd(mpETSC)Cl] complexes exhibit antineoplastic activity against colon cancer human cell lines (HCT 116).
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spelling pubmed-29097292010-07-29 Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO(2)(mpETSC)] and [Pt(mpETSC)Cl] Elsayed, Shadia A. El-Hendawy, Ahmed M. Mostafa, Sahar I. Jean-Claude, Bertrand J. Todorova, Margarita Butler, Ian S. Bioinorg Chem Appl Research Article New complexes of dioxovanadium(V), zinc(II), ruthenium(II), palladium(II), and platinum(II) with 6-methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone (HmpETSC) have been synthesized. The composition of these complexes is discussed on the basis of elemental analyses, IR, Raman, NMR ((1)H, (13)C, and (31)P), and electronic spectral data. The X-ray crystal structures of [VO(2)(mpETSC)] and [Pt(mpETSC)Cl] are also reported. The HmpETSC and its [Zn(HmpETSC)Cl(2)] and [Pd(mpETSC)Cl] complexes exhibit antineoplastic activity against colon cancer human cell lines (HCT 116). Hindawi Publishing Corporation 2010 2010-07-01 /pmc/articles/PMC2909729/ /pubmed/20671978 http://dx.doi.org/10.1155/2010/149149 Text en Copyright © 2010 Shadia A. Elsayed et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Elsayed, Shadia A.
El-Hendawy, Ahmed M.
Mostafa, Sahar I.
Jean-Claude, Bertrand J.
Todorova, Margarita
Butler, Ian S.
Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO(2)(mpETSC)] and [Pt(mpETSC)Cl]
title Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO(2)(mpETSC)] and [Pt(mpETSC)Cl]
title_full Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO(2)(mpETSC)] and [Pt(mpETSC)Cl]
title_fullStr Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO(2)(mpETSC)] and [Pt(mpETSC)Cl]
title_full_unstemmed Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO(2)(mpETSC)] and [Pt(mpETSC)Cl]
title_short Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO(2)(mpETSC)] and [Pt(mpETSC)Cl]
title_sort antineoplastic activity of new transition metal complexes of 6-methylpyridine-2-carbaldehyde-n(4)-ethylthiosemicarbazone: x-ray crystal structures of [vo(2)(mpetsc)] and [pt(mpetsc)cl]
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909729/
https://www.ncbi.nlm.nih.gov/pubmed/20671978
http://dx.doi.org/10.1155/2010/149149
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