Symptomatic hemorrhage after alteplase therapy not due to silent ischemia

BACKGROUND: Stroke thrombolysis-related intracerebral hemorrhage may occur remotely from the anatomical site of ischemia. One postulated mechanism for this is simultaneous multiple embolization with hemorrhage into a "silent" area of ischemia. RESULTS: A patient suffered a disabling stroke...

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Autores principales: Hill, Michael D, Barber, Philip A, Demchuk, Andrew M, Sevick, Robert J, Frayne, Richard, Buchan, Alastair M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29099/
https://www.ncbi.nlm.nih.gov/pubmed/11208259
http://dx.doi.org/10.1186/1471-2377-1-1
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author Hill, Michael D
Barber, Philip A
Demchuk, Andrew M
Sevick, Robert J
Frayne, Richard
Buchan, Alastair M
author_facet Hill, Michael D
Barber, Philip A
Demchuk, Andrew M
Sevick, Robert J
Frayne, Richard
Buchan, Alastair M
author_sort Hill, Michael D
collection PubMed
description BACKGROUND: Stroke thrombolysis-related intracerebral hemorrhage may occur remotely from the anatomical site of ischemia. One postulated mechanism for this is simultaneous multiple embolization with hemorrhage into a "silent" area of ischemia. RESULTS: A patient suffered a disabling stroke affecting the right cerebral hemisphere. He was treated with intravenous alteplase and underwent extensive early imaging with multimodal MRI. Several hours after treatment he developed a brainstem hemorrhage despite having no evidence of ischemia on DWI MRI in the brainstem. CONCLUSION: Not all occurrences of remote ICH after stroke thrombolysis are secondary to multiple emboli with silent ischemia.
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spelling pubmed-290992001-03-22 Symptomatic hemorrhage after alteplase therapy not due to silent ischemia Hill, Michael D Barber, Philip A Demchuk, Andrew M Sevick, Robert J Frayne, Richard Buchan, Alastair M BMC Neurol Case Report BACKGROUND: Stroke thrombolysis-related intracerebral hemorrhage may occur remotely from the anatomical site of ischemia. One postulated mechanism for this is simultaneous multiple embolization with hemorrhage into a "silent" area of ischemia. RESULTS: A patient suffered a disabling stroke affecting the right cerebral hemisphere. He was treated with intravenous alteplase and underwent extensive early imaging with multimodal MRI. Several hours after treatment he developed a brainstem hemorrhage despite having no evidence of ischemia on DWI MRI in the brainstem. CONCLUSION: Not all occurrences of remote ICH after stroke thrombolysis are secondary to multiple emboli with silent ischemia. BioMed Central 2001-01-19 /pmc/articles/PMC29099/ /pubmed/11208259 http://dx.doi.org/10.1186/1471-2377-1-1 Text en Copyright © 2001 Hill et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Case Report
Hill, Michael D
Barber, Philip A
Demchuk, Andrew M
Sevick, Robert J
Frayne, Richard
Buchan, Alastair M
Symptomatic hemorrhage after alteplase therapy not due to silent ischemia
title Symptomatic hemorrhage after alteplase therapy not due to silent ischemia
title_full Symptomatic hemorrhage after alteplase therapy not due to silent ischemia
title_fullStr Symptomatic hemorrhage after alteplase therapy not due to silent ischemia
title_full_unstemmed Symptomatic hemorrhage after alteplase therapy not due to silent ischemia
title_short Symptomatic hemorrhage after alteplase therapy not due to silent ischemia
title_sort symptomatic hemorrhage after alteplase therapy not due to silent ischemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29099/
https://www.ncbi.nlm.nih.gov/pubmed/11208259
http://dx.doi.org/10.1186/1471-2377-1-1
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AT sevickrobertj symptomatichemorrhageafteralteplasetherapynotduetosilentischemia
AT fraynerichard symptomatichemorrhageafteralteplasetherapynotduetosilentischemia
AT buchanalastairm symptomatichemorrhageafteralteplasetherapynotduetosilentischemia

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