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Adaphostin toxicity in a sensitive non-small cell lung cancer model is mediated through Nrf2 signaling and heme oxygenase 1

BACKGROUND: Preclinical toxicity of adaphostin has been related to oxidative stress. This study investigated the regulatory mechanism underlying adaphostin induction of heme oxygenase 1 (HMOX1) which plays a significant role in modulation of drug-induced toxicity in the non-small cell lung cancer ce...

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Detalles Bibliográficos
Autores principales:	Fer, Nicole D, Shoemaker, Robert H, Monks, Anne
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909968/ https://www.ncbi.nlm.nih.gov/pubmed/20618971 http://dx.doi.org/10.1186/1756-9966-29-91

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