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How is the balance between protein synthesis and degradation achieved?

Unlike most substances that cells manufacture, proteins are not produced and broken down by a common series of chemical reactions, but by completely different (independent and disconnected) mechanisms that possess no intrinsic means of making the rates of the two processes equal and attaining steady...

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Detalles Bibliográficos
Autor principal: Rothman, Stephen
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909984/
https://www.ncbi.nlm.nih.gov/pubmed/20573219
http://dx.doi.org/10.1186/1742-4682-7-25
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author Rothman, Stephen
author_facet Rothman, Stephen
author_sort Rothman, Stephen
collection PubMed
description Unlike most substances that cells manufacture, proteins are not produced and broken down by a common series of chemical reactions, but by completely different (independent and disconnected) mechanisms that possess no intrinsic means of making the rates of the two processes equal and attaining steady state concentrations. Balance between them is achieved extrinsically and is often imagined today to be the result of the actions of chemical feedback agents. But however instantiated, chemical feedback or any similar mechanism can only rectify induced imbalances in a system previously balanced by other means. Those "other means" necessarily involve reversible mass action or equilibrium-based interactions between native and altered forms of protein molecules somewhere in time and space between their synthesis and degradation.
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spelling pubmed-29099842010-07-27 How is the balance between protein synthesis and degradation achieved? Rothman, Stephen Theor Biol Med Model Research Unlike most substances that cells manufacture, proteins are not produced and broken down by a common series of chemical reactions, but by completely different (independent and disconnected) mechanisms that possess no intrinsic means of making the rates of the two processes equal and attaining steady state concentrations. Balance between them is achieved extrinsically and is often imagined today to be the result of the actions of chemical feedback agents. But however instantiated, chemical feedback or any similar mechanism can only rectify induced imbalances in a system previously balanced by other means. Those "other means" necessarily involve reversible mass action or equilibrium-based interactions between native and altered forms of protein molecules somewhere in time and space between their synthesis and degradation. BioMed Central 2010-06-23 /pmc/articles/PMC2909984/ /pubmed/20573219 http://dx.doi.org/10.1186/1742-4682-7-25 Text en Copyright ©2010 Rothman; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Rothman, Stephen
How is the balance between protein synthesis and degradation achieved?
title How is the balance between protein synthesis and degradation achieved?
title_full How is the balance between protein synthesis and degradation achieved?
title_fullStr How is the balance between protein synthesis and degradation achieved?
title_full_unstemmed How is the balance between protein synthesis and degradation achieved?
title_short How is the balance between protein synthesis and degradation achieved?
title_sort how is the balance between protein synthesis and degradation achieved?
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909984/
https://www.ncbi.nlm.nih.gov/pubmed/20573219
http://dx.doi.org/10.1186/1742-4682-7-25
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