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Gene activation regresses atherosclerosis, promotes health, and enhances longevity

BACKGROUND: Lifestyle factors and pharmacological compounds activate genetic mechanisms that influence the development of atherosclerotic and other diseases. This article reviews studies on natural and pharmacological gene activation that promotes health and enhances longevity. RESULTS: Living habit...

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Autor principal: Luoma, Pauli V
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909992/
https://www.ncbi.nlm.nih.gov/pubmed/20604930
http://dx.doi.org/10.1186/1476-511X-9-67
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author Luoma, Pauli V
author_facet Luoma, Pauli V
author_sort Luoma, Pauli V
collection PubMed
description BACKGROUND: Lifestyle factors and pharmacological compounds activate genetic mechanisms that influence the development of atherosclerotic and other diseases. This article reviews studies on natural and pharmacological gene activation that promotes health and enhances longevity. RESULTS: Living habits including healthy diet and regular physical activity, and pharmacotherapy, upregulate genes encoding enzymes and apolipoprotein and ATP-binding cassette transporters, acting in metabolic processes that promote health and increase survival. Cytochrome P450-enzymes, physiological factors in maintaining cholesterol homeostasis, generate oxysterols for the elimination of surplus cholesterol. Hepatic CTP:phosphocholine cytidylyltransferase-α is an important regulator of plasma HDL-C level. Gene-activators produce plasma lipoprotein profile, high HDL-C, HDL(2)-C and HDL-C/cholesterol ratio, which is typical of low risk of atherosclerotic disease, and also of exceptional longevity together with reduced prevalence of cardiovascular, metabolic and other diseases. High HDL contributes to protection against inflammation, oxidation and thrombosis, and associates with good cognitive function in very old people. Avoiding unhealthy stress and managing it properly promotes health and increases life expectancy. CONCLUSIONS: Healthy living habits and gene-activating xenobiotics upregulate mechanisms that produce lipoprotein pattern typical of very old people and enhance longevity. Lipoprotein metabolism and large HDL(2 )associate with the process of living a very long life. Major future goals for health promotion are the improving of commitment to both wise lifestyle choices and drug therapy, and further the developing of new and more effective and well tolerated drugs and treatments.
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spelling pubmed-29099922010-07-27 Gene activation regresses atherosclerosis, promotes health, and enhances longevity Luoma, Pauli V Lipids Health Dis Review BACKGROUND: Lifestyle factors and pharmacological compounds activate genetic mechanisms that influence the development of atherosclerotic and other diseases. This article reviews studies on natural and pharmacological gene activation that promotes health and enhances longevity. RESULTS: Living habits including healthy diet and regular physical activity, and pharmacotherapy, upregulate genes encoding enzymes and apolipoprotein and ATP-binding cassette transporters, acting in metabolic processes that promote health and increase survival. Cytochrome P450-enzymes, physiological factors in maintaining cholesterol homeostasis, generate oxysterols for the elimination of surplus cholesterol. Hepatic CTP:phosphocholine cytidylyltransferase-α is an important regulator of plasma HDL-C level. Gene-activators produce plasma lipoprotein profile, high HDL-C, HDL(2)-C and HDL-C/cholesterol ratio, which is typical of low risk of atherosclerotic disease, and also of exceptional longevity together with reduced prevalence of cardiovascular, metabolic and other diseases. High HDL contributes to protection against inflammation, oxidation and thrombosis, and associates with good cognitive function in very old people. Avoiding unhealthy stress and managing it properly promotes health and increases life expectancy. CONCLUSIONS: Healthy living habits and gene-activating xenobiotics upregulate mechanisms that produce lipoprotein pattern typical of very old people and enhance longevity. Lipoprotein metabolism and large HDL(2 )associate with the process of living a very long life. Major future goals for health promotion are the improving of commitment to both wise lifestyle choices and drug therapy, and further the developing of new and more effective and well tolerated drugs and treatments. BioMed Central 2010-07-06 /pmc/articles/PMC2909992/ /pubmed/20604930 http://dx.doi.org/10.1186/1476-511X-9-67 Text en Copyright ©2010 Luoma; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Luoma, Pauli V
Gene activation regresses atherosclerosis, promotes health, and enhances longevity
title Gene activation regresses atherosclerosis, promotes health, and enhances longevity
title_full Gene activation regresses atherosclerosis, promotes health, and enhances longevity
title_fullStr Gene activation regresses atherosclerosis, promotes health, and enhances longevity
title_full_unstemmed Gene activation regresses atherosclerosis, promotes health, and enhances longevity
title_short Gene activation regresses atherosclerosis, promotes health, and enhances longevity
title_sort gene activation regresses atherosclerosis, promotes health, and enhances longevity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909992/
https://www.ncbi.nlm.nih.gov/pubmed/20604930
http://dx.doi.org/10.1186/1476-511X-9-67
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