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Gene silencing induced by oxidative DNA base damage: association with local decrease of histone H4 acetylation in the promoter region

Oxidized DNA bases, particularly 7,8-dihydro-8-oxoguanine (8-oxoG), are endogenously generated in cells, being a cause of carcinogenic mutations and possibly interfering with gene expression. We found that expression of an oxidatively damaged plasmid DNA is impaired after delivery into human host ce...

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Detalles Bibliográficos
Autores principales:	Khobta, Andriy, Anderhub, Simon, Kitsera, Nataliya, Epe, Bernd
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Gene Regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910050/ https://www.ncbi.nlm.nih.gov/pubmed/20338881 http://dx.doi.org/10.1093/nar/gkq170

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