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Loop Electrosurgical Excisional Procedure (LEEP) Done for Discrepancy: Does the Time from HGSIL Affect Pathologic Grade of CIN in LEEP Specimen?

Objective. When pathologic discrepancy arises between high-grade cytology on Papanicolaou (Pap) smear and low-grade histology on cervical biopsy, Loop Electrosurgical Excisional Procedure (LEEP) is one management alternative. Our objective was to determine whether the time from initial HGSIL Pap to...

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Autores principales: Moreni, Sue L., Mitchell, Caroline M., Garcia, Rochelle L., Eckert, Linda O.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910507/
https://www.ncbi.nlm.nih.gov/pubmed/20671925
http://dx.doi.org/10.1155/2010/743097
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author Moreni, Sue L.
Mitchell, Caroline M.
Garcia, Rochelle L.
Eckert, Linda O.
author_facet Moreni, Sue L.
Mitchell, Caroline M.
Garcia, Rochelle L.
Eckert, Linda O.
author_sort Moreni, Sue L.
collection PubMed
description Objective. When pathologic discrepancy arises between high-grade cytology on Papanicolaou (Pap) smear and low-grade histology on cervical biopsy, Loop Electrosurgical Excisional Procedure (LEEP) is one management alternative. Our objective was to determine whether the time from initial HGSIL Pap to LEEP affects the pathologic grade of the LEEP specimen. Study Design. We performed a retrospective case-control study identifying LEEPs performed for discrepancy over a 10-year period (1997–2007). 121 subjects were separated into two groups based on LEEP pathology (≤CIN 1 and CIN 2,3) and compared using χ (2). Results. Of the 121 LEEP specimens, 67 (55.4%) had CIN 2,3. CIN 2,3 was more often discovered when LEEP was performed within 3 months of the HGSIL Pap smear versus after 5 months (55.2% versus 16.4%, P = .096). Conclusion. Women undergoing LEEP for discrepancy >5 months from their HGSIL Pap demonstrated a trend toward less CIN 2,3 on LEEP pathology.
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spelling pubmed-29105072010-07-29 Loop Electrosurgical Excisional Procedure (LEEP) Done for Discrepancy: Does the Time from HGSIL Affect Pathologic Grade of CIN in LEEP Specimen? Moreni, Sue L. Mitchell, Caroline M. Garcia, Rochelle L. Eckert, Linda O. Obstet Gynecol Int Clinical Study Objective. When pathologic discrepancy arises between high-grade cytology on Papanicolaou (Pap) smear and low-grade histology on cervical biopsy, Loop Electrosurgical Excisional Procedure (LEEP) is one management alternative. Our objective was to determine whether the time from initial HGSIL Pap to LEEP affects the pathologic grade of the LEEP specimen. Study Design. We performed a retrospective case-control study identifying LEEPs performed for discrepancy over a 10-year period (1997–2007). 121 subjects were separated into two groups based on LEEP pathology (≤CIN 1 and CIN 2,3) and compared using χ (2). Results. Of the 121 LEEP specimens, 67 (55.4%) had CIN 2,3. CIN 2,3 was more often discovered when LEEP was performed within 3 months of the HGSIL Pap smear versus after 5 months (55.2% versus 16.4%, P = .096). Conclusion. Women undergoing LEEP for discrepancy >5 months from their HGSIL Pap demonstrated a trend toward less CIN 2,3 on LEEP pathology. Hindawi Publishing Corporation 2010 2010-06-29 /pmc/articles/PMC2910507/ /pubmed/20671925 http://dx.doi.org/10.1155/2010/743097 Text en Copyright © 2010 Sue L. Moreni et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Moreni, Sue L.
Mitchell, Caroline M.
Garcia, Rochelle L.
Eckert, Linda O.
Loop Electrosurgical Excisional Procedure (LEEP) Done for Discrepancy: Does the Time from HGSIL Affect Pathologic Grade of CIN in LEEP Specimen?
title Loop Electrosurgical Excisional Procedure (LEEP) Done for Discrepancy: Does the Time from HGSIL Affect Pathologic Grade of CIN in LEEP Specimen?
title_full Loop Electrosurgical Excisional Procedure (LEEP) Done for Discrepancy: Does the Time from HGSIL Affect Pathologic Grade of CIN in LEEP Specimen?
title_fullStr Loop Electrosurgical Excisional Procedure (LEEP) Done for Discrepancy: Does the Time from HGSIL Affect Pathologic Grade of CIN in LEEP Specimen?
title_full_unstemmed Loop Electrosurgical Excisional Procedure (LEEP) Done for Discrepancy: Does the Time from HGSIL Affect Pathologic Grade of CIN in LEEP Specimen?
title_short Loop Electrosurgical Excisional Procedure (LEEP) Done for Discrepancy: Does the Time from HGSIL Affect Pathologic Grade of CIN in LEEP Specimen?
title_sort loop electrosurgical excisional procedure (leep) done for discrepancy: does the time from hgsil affect pathologic grade of cin in leep specimen?
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910507/
https://www.ncbi.nlm.nih.gov/pubmed/20671925
http://dx.doi.org/10.1155/2010/743097
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