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A case-control study of autism and mumps-measles-rubella vaccination using the general practice research database: design and methodology

BACKGROUND: An association between mumps-measles-rubella (MMR) vaccination and the onset of symptoms typical of autism has recently been suggested. This has led to considerable concern about the safety of the vaccine. METHODS: A matched case-control study using data derived form the United Kingdom G...

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Autores principales: Smeeth, Liam, Hall, Andrew J, Fombonne, Eric, Rodrigues, Laura C, Huang, Xiangning, Smith, Peter G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29106/
https://www.ncbi.nlm.nih.gov/pubmed/11231881
http://dx.doi.org/10.1186/1471-2458-1-2
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author Smeeth, Liam
Hall, Andrew J
Fombonne, Eric
Rodrigues, Laura C
Huang, Xiangning
Smith, Peter G
author_facet Smeeth, Liam
Hall, Andrew J
Fombonne, Eric
Rodrigues, Laura C
Huang, Xiangning
Smith, Peter G
author_sort Smeeth, Liam
collection PubMed
description BACKGROUND: An association between mumps-measles-rubella (MMR) vaccination and the onset of symptoms typical of autism has recently been suggested. This has led to considerable concern about the safety of the vaccine. METHODS: A matched case-control study using data derived form the United Kingdom General Practice Research Database. Children with a possible diagnosis of autism will be identified from their electronic health records. All diagnoses will be validated by a detailed review of hospital letters and by using information derived from a parental questionnaire. Ten controls per case will be selected from the database. Conditional logistic regression will be used to assess the association between MMR vaccination and autism. In addition case series analyses will be undertaken to estimate the relative incidence of onset of autism in defined time intervals after vaccination. The study is funded by the United Kingdom Medical Research Council. DISCUSSION: Electronic health databases offer tremendous opportunities for evaluating the adverse effects of vaccines. However there is much scope for bias and confounding. The rigorous validation of all diagnoses and the collection of additional information by parental questionnaire in this study are essential to minimise the possibility of misleading results.
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spelling pubmed-291062001-03-22 A case-control study of autism and mumps-measles-rubella vaccination using the general practice research database: design and methodology Smeeth, Liam Hall, Andrew J Fombonne, Eric Rodrigues, Laura C Huang, Xiangning Smith, Peter G BMC Public Health Study Protocol BACKGROUND: An association between mumps-measles-rubella (MMR) vaccination and the onset of symptoms typical of autism has recently been suggested. This has led to considerable concern about the safety of the vaccine. METHODS: A matched case-control study using data derived form the United Kingdom General Practice Research Database. Children with a possible diagnosis of autism will be identified from their electronic health records. All diagnoses will be validated by a detailed review of hospital letters and by using information derived from a parental questionnaire. Ten controls per case will be selected from the database. Conditional logistic regression will be used to assess the association between MMR vaccination and autism. In addition case series analyses will be undertaken to estimate the relative incidence of onset of autism in defined time intervals after vaccination. The study is funded by the United Kingdom Medical Research Council. DISCUSSION: Electronic health databases offer tremendous opportunities for evaluating the adverse effects of vaccines. However there is much scope for bias and confounding. The rigorous validation of all diagnoses and the collection of additional information by parental questionnaire in this study are essential to minimise the possibility of misleading results. BioMed Central 2001-02-15 /pmc/articles/PMC29106/ /pubmed/11231881 http://dx.doi.org/10.1186/1471-2458-1-2 Text en Copyright © 2001 Smeeth et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Study Protocol
Smeeth, Liam
Hall, Andrew J
Fombonne, Eric
Rodrigues, Laura C
Huang, Xiangning
Smith, Peter G
A case-control study of autism and mumps-measles-rubella vaccination using the general practice research database: design and methodology
title A case-control study of autism and mumps-measles-rubella vaccination using the general practice research database: design and methodology
title_full A case-control study of autism and mumps-measles-rubella vaccination using the general practice research database: design and methodology
title_fullStr A case-control study of autism and mumps-measles-rubella vaccination using the general practice research database: design and methodology
title_full_unstemmed A case-control study of autism and mumps-measles-rubella vaccination using the general practice research database: design and methodology
title_short A case-control study of autism and mumps-measles-rubella vaccination using the general practice research database: design and methodology
title_sort case-control study of autism and mumps-measles-rubella vaccination using the general practice research database: design and methodology
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29106/
https://www.ncbi.nlm.nih.gov/pubmed/11231881
http://dx.doi.org/10.1186/1471-2458-1-2
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