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Modulation of mdm2 pre-mRNA splicing by 9-aminoacridine-PNA (peptide nucleic acid) conjugates targeting intron-exon junctions

BACKGROUND: Modulation of pre-mRNA splicing by antisense molecules is a promising mechanism of action for gene therapeutic drugs. In this study, we have examined the potential of peptide nucleic acid (PNA) 9-aminoacridine conjugates to modulate the pre-mRNA splicing of the mdm2 human cancer gene in...

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Detalles Bibliográficos
Autores principales:	Shiraishi, Takehiko, Eysturskarð, Jonhard, Nielsen, Peter E
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910690/ https://www.ncbi.nlm.nih.gov/pubmed/20591158 http://dx.doi.org/10.1186/1471-2407-10-342

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