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Absence of Inhibin Alpha and Retinoblastoma Protein Leads to Early Sertoli Cell Dysfunction

Sertoli cells, the support cells of mammalian spermatogenesis, are regulated by a number of nuclear factors and express retinoblastoma (RB) tumor suppressor protein. We hypothesized that RB is an important mediator of Sertoli cell tumorigenesis in inhibin α knockout (Inha KO) mice. In our previous m...

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Detalles Bibliográficos
Autores principales: Nalam, Roopa L., Andreu-Vieyra, Claudia, Matzuk, Martin M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910728/
https://www.ncbi.nlm.nih.gov/pubmed/20676395
http://dx.doi.org/10.1371/journal.pone.0011797