High risk of essential hypertension in males with intron 4 VNTR polymorphism of eNOS gene

In this study 250 patients with essential hypertension were investigated in comparison to 218 normotensives for association with epidemiological parameters. Of these DNA samples from 176 patients and 168 controls were analyzed for intron 4 27bp repeat polymorphism of eNOS gene. The study revealed si...

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Detalles Bibliográficos
Autores principales: Patkar, Sushma, Charita, B. H., Ramesh, C., Padma, T
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910948/
https://www.ncbi.nlm.nih.gov/pubmed/20680151
http://dx.doi.org/10.4103/0971-6866.55215
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author Patkar, Sushma
Charita, B. H.
Ramesh, C.
Padma, T
author_facet Patkar, Sushma
Charita, B. H.
Ramesh, C.
Padma, T
author_sort Patkar, Sushma
collection PubMed
description In this study 250 patients with essential hypertension were investigated in comparison to 218 normotensives for association with epidemiological parameters. Of these DNA samples from 176 patients and 168 controls were analyzed for intron 4 27bp repeat polymorphism of eNOS gene. The study revealed significantly high risk of essential hypertension for individuals who were obese, with a positive family history and with non-vegetarian food habits. Though the intron 4b/a polymorphism of eNOS gene did not reveal any association with essential hypertension in general, males with a/a genotype of the polymorphism did show significantly high risk for developing hypertension.
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spelling pubmed-29109482010-08-02 High risk of essential hypertension in males with intron 4 VNTR polymorphism of eNOS gene Patkar, Sushma Charita, B. H. Ramesh, C. Padma, T Indian J Hum Genet Original Article In this study 250 patients with essential hypertension were investigated in comparison to 218 normotensives for association with epidemiological parameters. Of these DNA samples from 176 patients and 168 controls were analyzed for intron 4 27bp repeat polymorphism of eNOS gene. The study revealed significantly high risk of essential hypertension for individuals who were obese, with a positive family history and with non-vegetarian food habits. Though the intron 4b/a polymorphism of eNOS gene did not reveal any association with essential hypertension in general, males with a/a genotype of the polymorphism did show significantly high risk for developing hypertension. Medknow Publications 2009 /pmc/articles/PMC2910948/ /pubmed/20680151 http://dx.doi.org/10.4103/0971-6866.55215 Text en © Indian Journal of Human Genetics http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Patkar, Sushma
Charita, B. H.
Ramesh, C.
Padma, T
High risk of essential hypertension in males with intron 4 VNTR polymorphism of eNOS gene
title High risk of essential hypertension in males with intron 4 VNTR polymorphism of eNOS gene
title_full High risk of essential hypertension in males with intron 4 VNTR polymorphism of eNOS gene
title_fullStr High risk of essential hypertension in males with intron 4 VNTR polymorphism of eNOS gene
title_full_unstemmed High risk of essential hypertension in males with intron 4 VNTR polymorphism of eNOS gene
title_short High risk of essential hypertension in males with intron 4 VNTR polymorphism of eNOS gene
title_sort high risk of essential hypertension in males with intron 4 vntr polymorphism of enos gene
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910948/
https://www.ncbi.nlm.nih.gov/pubmed/20680151
http://dx.doi.org/10.4103/0971-6866.55215
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