Increased β-Cell Mass by Islet Transplantation and PLAG1 Overexpression Causes Hyperinsulinemic Normoglycemia and Hepatic Insulin Resistance in Mice

OBJECTIVE: It is believed that an organism remains normoglycemic despite an increase in the β-cell mass because of decreased insulin production by β-cells on a per-cell basis. However, some transgenic mouse models with β-cell hyperplasia suggest that insulin production remains excessive and that nor...

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Detalles Bibliográficos
Autores principales: Declercq, Jeroen, Kumar, Anujith, Van Diepen, Janna A., Vroegrijk, Irene O.C.M., Gysemans, Conny, Di Pietro, Caterina, Voshol, Peter J., Mathieu, Chantal, Ectors, Nadine, Van de Ven, Wim J.M., Verfaillie, Catherine M.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911055/
https://www.ncbi.nlm.nih.gov/pubmed/20522588
http://dx.doi.org/10.2337/db09-1446

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