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Deficiency of Rac1 Blocks NADPH Oxidase Activation, Inhibits Endoplasmic Reticulum Stress, and Reduces Myocardial Remodeling in a Mouse Model of Type 1 Diabetes

OBJECTIVE: Our recent study demonstrated that Rac1 and NADPH oxidase activation contributes to cardiomyocyte apoptosis in short-term diabetes. This study was undertaken to investigate if disruption of Rac1 and inhibition of NADPH oxidase would prevent myocardial remodeling in chronic diabetes. RESEA...

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Detalles Bibliográficos
Autores principales:	Li, Jianmin, Zhu, Huaqing, Shen, E, Wan, Li, Arnold, J. Malcolm O., Peng, Tianqing
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Complications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911061/ https://www.ncbi.nlm.nih.gov/pubmed/20522592 http://dx.doi.org/10.2337/db09-1800

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