Cargando…

Transient Inhibition of Transforming Growth Factor-β1 in Human Diabetic CD34(+) Cells Enhances Vascular Reparative Functions

OBJECTIVE: Peripheral blood CD34(+) cells from diabetic patients demonstrate reduced vascular reparative function due to decreased proliferation and diminished migratory prowess, largely resulting from decreased nitric oxide (NO) bioavailability. The level of TGF-β, a key factor that modulates stem...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhatwadekar, Ashay D., Guerin, E.P., Jarajapu, Yagna P.R., Caballero, Sergio, Sheridan, Carl, Kent, David, Kennedy, Laurence, Lansang, M. Cecilia, Ruscetti, Frank W., Pepine, Carl J., Higgins, Paul J., Bartelmez, Stephen H., Grant, Maria B.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Complications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911069/ https://www.ncbi.nlm.nih.gov/pubmed/20460428 http://dx.doi.org/10.2337/db10-0287

Ejemplares similares

Reversal of Bone Marrow Mobilopathy and Enhanced Vascular Repair by Angiotensin-(1-7) in Diabetes
por: Vasam, Goutham, et al.
Publicado: (2017)

miR-92a Corrects CD34(+) Cell Dysfunction in Diabetes by Modulating Core Circadian Genes Involved in Progenitor Differentiation
por: Bhatwadekar, Ashay D., et al.
Publicado: (2015)

Activation of the ACE2/Angiotensin-(1–7)/Mas Receptor Axis Enhances the Reparative Function of Dysfunctional Diabetic Endothelial Progenitors
por: Jarajapu, Yagna P.R., et al.
Publicado: (2013)

Enhancing the Function of CD34(+) Cells by Targeting Plasminogen Activator Inhibitor-1
por: Hazra, Sugata, et al.
Publicado: (2013)

Dapagliflozin protects neural and vascular dysfunction of the retina in diabetes
por: Luo, Qianyi, et al.
Publicado: (2022)

Impaired Mobilization of Vascular Reparative Bone Marrow Cells in Streptozotocin-Induced Diabetes but not in Leptin Receptor-Deficient db/db Mice
por: Vasam, Goutham, et al.
Publicado: (2016)

Liver X Receptor Modulates Diabetic Retinopathy Outcome in a Mouse Model of Streptozotocin-Induced Diabetes
por: Hazra, Sugata, et al.
Publicado: (2012)

Per2 Mutation Recapitulates the Vascular Phenotype of Diabetes in the Retina and Bone Marrow
por: Bhatwadekar, Ashay D., et al.
Publicado: (2013)

GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop
por: Giacco, Ferdinando, et al.
Publicado: (2015)

The association between vaginal bacterial composition and miscarriage: a nested case–control study
por: Al‐Memar, M, et al.
Publicado: (2019)

Hypohalous Acids Contribute to Renal Extracellular Matrix Damage in Experimental Diabetes
por: Brown, Kyle L., et al.
Publicado: (2015)

Editorial: The role of macrophages in metabolic disorders
por: Jarajapu, Yagna P. R., et al.
Publicado: (2023)

Effects of TRAM-34 and minocycline on neuroinflammation caused by diabetic ketoacidosis in a rat model
por: Glaser, Nicole, et al.
Publicado: (2022)

Partial Inhibition of Insulin Secretion Results in Glucose Intolerance but Not Hyperglucagonemia
por: Ramanathan, Ranjani P., et al.
Publicado: (2011)

Impact of C-Peptide Preservation on Metabolic and Clinical Outcomes in the Diabetes Control and Complications Trial
por: Lachin, John M., et al.
Publicado: (2014)

Heritable Transmission of Diabetic Metabolic Memory in Zebrafish Correlates With DNA Hypomethylation and Aberrant Gene Expression
por: Olsen, Ansgar S., et al.
Publicado: (2012)

Parp Inhibition Prevents Ten-Eleven Translocase Enzyme Activation and Hyperglycemia-Induced DNA Demethylation
por: Dhliwayo, Nyembezi, et al.
Publicado: (2014)

Toll-Like Receptor 4 Activation Contributes to Diabetic Bladder Dysfunction in a Murine Model of Type 1 Diabetes
por: Szasz, Theodora, et al.
Publicado: (2016)

Editorial: Cell-Based Therapies for Diabetic Microvascular Complications
por: Bhatwadekar, Ashay D.
Publicado: (2015)

Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity
por: Grillo, Claudia A., et al.
Publicado: (2015)

Inhibition of Plasminogen Activator Inhibitor-1 Restores Skeletal Muscle Regeneration in Untreated Type 1 Diabetic Mice
por: Krause, Matthew P., et al.
Publicado: (2011)

Plasma Exosomes Contribute to Microvascular Damage in Diabetic Retinopathy by Activating the Classical Complement Pathway
por: Huang, Chao, et al.
Publicado: (2018)

Plasma Kallikrein Mediates Retinal Vascular Dysfunction and Induces Retinal Thickening in Diabetic Rats
por: Clermont, Allen, et al.
Publicado: (2011)

The Association of Hemoglobin A1c With Incident Heart Failure Among People Without Diabetes: The Atherosclerosis Risk in Communities Study
por: Matsushita, Kunihiro, et al.
Publicado: (2010)

Circulating TGF-β1–Regulated miRNAs and the Risk of Rapid Progression to ESRD in Type 1 Diabetes
por: Pezzolesi, Marcus G., et al.
Publicado: (2015)

Glycemic Control and Cardiovascular Mortality in Hemodialysis Patients With Diabetes: A 6-Year Cohort Study
por: Ricks, Joni, et al.
Publicado: (2012)

Diabetes-Induced NF-κB Dysregulation in Skeletal Stem Cells Prevents Resolution of Inflammation
por: Ko, Kang I., et al.
Publicado: (2019)

Diffusion Tensor Imaging Identifies Deficits in White Matter Microstructure in Subjects With Type 1 Diabetes That Correlate With Reduced Neurocognitive Function
por: Kodl, Christopher T., et al.
Publicado: (2008)

REDD1 Ablation Attenuates the Development of Renal Complications in Diabetic Mice
por: Sunilkumar, Siddharth, et al.
Publicado: (2022)

Slowing of Peripheral Nerve Conduction Velocity in Children and Adolescents With Type 1 Diabetes Is Predicted by Glucose Fluctuations
por: Oberhauser, Sarah S., et al.
Publicado: (2023)

Progression of Carotid Artery Intima-Media Thickness During 12 Years in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study
por: Polak, Joseph F., et al.
Publicado: (2011)

Müller Glial Expression of REDD1 Is Required for Retinal Neurodegeneration and Visual Dysfunction in Diabetic Mice
por: Miller, William P., et al.
Publicado: (2022)

Activation of Disulfide Redox Switch in REDD1 Promotes Oxidative Stress Under Hyperglycemic Conditions
por: Miller, William P., et al.
Publicado: (2022)

Carbonylation Contributes to SERCA2a Activity Loss and Diastolic Dysfunction in a Rat Model of Type 1 Diabetes
por: Shao, Chun Hong, et al.
Publicado: (2011)

Correction of HDL Dysfunction in Individuals With Diabetes and the Haptoglobin 2-2 Genotype
por: Asleh, Rabea, et al.
Publicado: (2008)

Overexpressing IRS1 in Endothelial Cells Enhances Angioblast Differentiation and Wound Healing in Diabetes and Insulin Resistance
por: Katagiri, Sayaka, et al.
Publicado: (2016)

Inhibition of TNF-α Improves the Bladder Dysfunction That Is Associated With Type 2 Diabetes
por: Wang, Zongwei, et al.
Publicado: (2012)

Cerebral White Matter Integrity and Resting-State Functional Connectivity in Middle-aged Patients With Type 2 Diabetes
por: Hoogenboom, Wouter S., et al.
Publicado: (2014)

Existence of a Colonizing Staphylococcus aureus Strain Isolated in Diabetic Foot Ulcers
por: Messad, Nourreddine, et al.
Publicado: (2015)

Alagebrium Reduces Glomerular Fibrogenesis and Inflammation Beyond Preventing RAGE Activation in Diabetic Apolipoprotein E Knockout Mice
por: Watson, Anna M.D., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_vgbvglg8hfdhjnnklsn1sfiqav