Increased Cytochrome P4502E1 Expression and Altered Hydroxyeicosatetraenoic Acid Formation Mediate Diabetic Vascular Dysfunction: Rescue by Guanylyl-Cyclase Activation

OBJECTIVE: We investigated the mechanisms underlying vascular endothelial and contractile dysfunction in diabetes as well as the effect of HMR1766, a novel nitric oxide (NO)-independent activator of soluble guanylyl cyclase (sGC). RESEARCH DESIGN AND METHODS: Two weeks after induction of diabetes by...

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Detalles Bibliográficos
Autores principales: Schäfer, Andreas, Galuppo, Paolo, Fraccarollo, Daniela, Vogt, Christian, Widder, Julian D., Pfrang, Julia, Tas, Piet, Barbosa-Sicard, Eduardo, Ruetten, Hartmut, Ertl, Georg, Fleming, Ingrid, Bauersachs, Johann
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Pathophysiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911073/
https://www.ncbi.nlm.nih.gov/pubmed/20522591
http://dx.doi.org/10.2337/db09-1668

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