Escape from X inactivation in mice and humans

A subset of X-linked genes escapes silencing by X inactivation and is expressed from both X chromosomes in mammalian females. Species-specific differences in the identity of these genes have recently been discovered, suggesting a role in the evolution of sex differences. Chromatin analyses have aime...

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Detalles Bibliográficos
Autores principales: Berletch, Joel B, Yang, Fan, Disteche, Christine M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911101/
https://www.ncbi.nlm.nih.gov/pubmed/20573260
http://dx.doi.org/10.1186/gb-2010-11-6-213
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author Berletch, Joel B
Yang, Fan
Disteche, Christine M
author_facet Berletch, Joel B
Yang, Fan
Disteche, Christine M
author_sort Berletch, Joel B
collection PubMed
description A subset of X-linked genes escapes silencing by X inactivation and is expressed from both X chromosomes in mammalian females. Species-specific differences in the identity of these genes have recently been discovered, suggesting a role in the evolution of sex differences. Chromatin analyses have aimed to discover how genes remain expressed within a repressive environment.
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spelling pubmed-29111012011-06-24 Escape from X inactivation in mice and humans Berletch, Joel B Yang, Fan Disteche, Christine M Genome Biol Review A subset of X-linked genes escapes silencing by X inactivation and is expressed from both X chromosomes in mammalian females. Species-specific differences in the identity of these genes have recently been discovered, suggesting a role in the evolution of sex differences. Chromatin analyses have aimed to discover how genes remain expressed within a repressive environment. BioMed Central 2010 2010-06-24 /pmc/articles/PMC2911101/ /pubmed/20573260 http://dx.doi.org/10.1186/gb-2010-11-6-213 Text en Copyright ©2010 BioMed Central Ltd
spellingShingle Review
Berletch, Joel B
Yang, Fan
Disteche, Christine M
Escape from X inactivation in mice and humans
title Escape from X inactivation in mice and humans
title_full Escape from X inactivation in mice and humans
title_fullStr Escape from X inactivation in mice and humans
title_full_unstemmed Escape from X inactivation in mice and humans
title_short Escape from X inactivation in mice and humans
title_sort escape from x inactivation in mice and humans
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911101/
https://www.ncbi.nlm.nih.gov/pubmed/20573260
http://dx.doi.org/10.1186/gb-2010-11-6-213
work_keys_str_mv AT berletchjoelb escapefromxinactivationinmiceandhumans
AT yangfan escapefromxinactivationinmiceandhumans
AT distechechristinem escapefromxinactivationinmiceandhumans

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