Design, Synthesis, and Analysis of Minor Groove Binder Pyrrolepolyamide-2′-Deoxyguanosine Hybrids

Pyrrolepolyamide-2′-deoxyguanosine hybrids (Hybrid 2 and Hybrid 3) incorporating the 3-aminopropionyl or 3-aminopropyl linker were designed and synthesized on the basis of previously reported results of a pyrrolepolyamide-adenosine hybrid (Hybrid 1). Evaluation of the DNA binding sequence selectivit...

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Autores principales: Kawashima, Etsuko, Ohba, Yusuke, Terui, Yusuke, Kamaike, Kazuo
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911594/
https://www.ncbi.nlm.nih.gov/pubmed/20700414
http://dx.doi.org/10.4061/2010/235240
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author Kawashima, Etsuko
Ohba, Yusuke
Terui, Yusuke
Kamaike, Kazuo
author_facet Kawashima, Etsuko
Ohba, Yusuke
Terui, Yusuke
Kamaike, Kazuo
author_sort Kawashima, Etsuko
collection PubMed
description Pyrrolepolyamide-2′-deoxyguanosine hybrids (Hybrid 2 and Hybrid 3) incorporating the 3-aminopropionyl or 3-aminopropyl linker were designed and synthesized on the basis of previously reported results of a pyrrolepolyamide-adenosine hybrid (Hybrid 1). Evaluation of the DNA binding sequence selectivity of pyrrolepolyamide-2′-deoxyguanosine hybrids was performed by CD spectral and T (m) analyses. It was shown that Hybrid 3 possessed greater binding specificity than distamycin A, Hybrid 1 and Hybrid 2.
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spelling pubmed-29115942010-08-10 Design, Synthesis, and Analysis of Minor Groove Binder Pyrrolepolyamide-2′-Deoxyguanosine Hybrids Kawashima, Etsuko Ohba, Yusuke Terui, Yusuke Kamaike, Kazuo J Nucleic Acids Research Article Pyrrolepolyamide-2′-deoxyguanosine hybrids (Hybrid 2 and Hybrid 3) incorporating the 3-aminopropionyl or 3-aminopropyl linker were designed and synthesized on the basis of previously reported results of a pyrrolepolyamide-adenosine hybrid (Hybrid 1). Evaluation of the DNA binding sequence selectivity of pyrrolepolyamide-2′-deoxyguanosine hybrids was performed by CD spectral and T (m) analyses. It was shown that Hybrid 3 possessed greater binding specificity than distamycin A, Hybrid 1 and Hybrid 2. SAGE-Hindawi Access to Research 2010-02-16 /pmc/articles/PMC2911594/ /pubmed/20700414 http://dx.doi.org/10.4061/2010/235240 Text en Copyright © 2010 Etsuko Kawashima et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kawashima, Etsuko
Ohba, Yusuke
Terui, Yusuke
Kamaike, Kazuo
Design, Synthesis, and Analysis of Minor Groove Binder Pyrrolepolyamide-2′-Deoxyguanosine Hybrids
title Design, Synthesis, and Analysis of Minor Groove Binder Pyrrolepolyamide-2′-Deoxyguanosine Hybrids
title_full Design, Synthesis, and Analysis of Minor Groove Binder Pyrrolepolyamide-2′-Deoxyguanosine Hybrids
title_fullStr Design, Synthesis, and Analysis of Minor Groove Binder Pyrrolepolyamide-2′-Deoxyguanosine Hybrids
title_full_unstemmed Design, Synthesis, and Analysis of Minor Groove Binder Pyrrolepolyamide-2′-Deoxyguanosine Hybrids
title_short Design, Synthesis, and Analysis of Minor Groove Binder Pyrrolepolyamide-2′-Deoxyguanosine Hybrids
title_sort design, synthesis, and analysis of minor groove binder pyrrolepolyamide-2′-deoxyguanosine hybrids
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911594/
https://www.ncbi.nlm.nih.gov/pubmed/20700414
http://dx.doi.org/10.4061/2010/235240
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