Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling

The spindle assembly checkpoint (SAC) in mammals uses cytosolic and kinetochore-based signaling pathways to inhibit anaphase. In this study, we use chemical genetics to show that the protein kinase Mps1 regulates both aspects of the SAC. Human MPS1-null cells were generated via gene targeting and re...

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Detalles Bibliográficos
Autores principales: Maciejowski, John, George, Kelly A., Terret, Marie-Emilie, Zhang, Chao, Shokat, Kevan M., Jallepalli, Prasad V.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911671/
https://www.ncbi.nlm.nih.gov/pubmed/20624902
http://dx.doi.org/10.1083/jcb.201001050

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