A chemical tool box defines mitotic and interphase roles for Mps1 kinase

In this issue, three groups (Hewitt et al. 2010. J. Cell Biol. doi:10.1083/jcb.201002133; Maciejowski et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001050; Santaguida et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001036) use chemical inhibitors to analyze the function of the mitotic checkpoint kinas...

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Detalles Bibliográficos
Autores principales: Lan, Weijie, Cleveland, Don W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911672/
https://www.ncbi.nlm.nih.gov/pubmed/20624898
http://dx.doi.org/10.1083/jcb.201006080
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author Lan, Weijie
Cleveland, Don W.
author_facet Lan, Weijie
Cleveland, Don W.
author_sort Lan, Weijie
collection PubMed
description In this issue, three groups (Hewitt et al. 2010. J. Cell Biol. doi:10.1083/jcb.201002133; Maciejowski et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001050; Santaguida et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001036) use chemical inhibitors to analyze the function of the mitotic checkpoint kinase Mps1. These studies demonstrate that Mps1 kinase activity ensures accurate chromosome segregation through its recruitment to kinetochores of mitotic checkpoint proteins, formation of interphase and mitotic inhibitors of Cdc20, and correction of faulty microtubule attachments.
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spelling pubmed-29116722011-01-12 A chemical tool box defines mitotic and interphase roles for Mps1 kinase Lan, Weijie Cleveland, Don W. J Cell Biol Reviews In this issue, three groups (Hewitt et al. 2010. J. Cell Biol. doi:10.1083/jcb.201002133; Maciejowski et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001050; Santaguida et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001036) use chemical inhibitors to analyze the function of the mitotic checkpoint kinase Mps1. These studies demonstrate that Mps1 kinase activity ensures accurate chromosome segregation through its recruitment to kinetochores of mitotic checkpoint proteins, formation of interphase and mitotic inhibitors of Cdc20, and correction of faulty microtubule attachments. The Rockefeller University Press 2010-07-12 /pmc/articles/PMC2911672/ /pubmed/20624898 http://dx.doi.org/10.1083/jcb.201006080 Text en © 2010 Lan and Cleveland This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Lan, Weijie
Cleveland, Don W.
A chemical tool box defines mitotic and interphase roles for Mps1 kinase
title A chemical tool box defines mitotic and interphase roles for Mps1 kinase
title_full A chemical tool box defines mitotic and interphase roles for Mps1 kinase
title_fullStr A chemical tool box defines mitotic and interphase roles for Mps1 kinase
title_full_unstemmed A chemical tool box defines mitotic and interphase roles for Mps1 kinase
title_short A chemical tool box defines mitotic and interphase roles for Mps1 kinase
title_sort chemical tool box defines mitotic and interphase roles for mps1 kinase
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911672/
https://www.ncbi.nlm.nih.gov/pubmed/20624898
http://dx.doi.org/10.1083/jcb.201006080
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