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Does proteolysis explain glutamine release from the septic brain?

Berg and colleagues report on amino acid exchange across the human brain during endotoxin infusion. Lipopolysaccharide infusion induced a decrease in the ratio between branched chain amino acids and aromatic amino acids, increased unidirectional phenylalanine uptake, and increased net brain glutamin...

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Detalles Bibliográficos
Autores principales: Dejong, Cornelius HC, Olde Damink, Steven WM
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911689/
https://www.ncbi.nlm.nih.gov/pubmed/20497607
http://dx.doi.org/10.1186/cc8971
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author Dejong, Cornelius HC
Olde Damink, Steven WM
author_facet Dejong, Cornelius HC
Olde Damink, Steven WM
author_sort Dejong, Cornelius HC
collection PubMed
description Berg and colleagues report on amino acid exchange across the human brain during endotoxin infusion. Lipopolysaccharide infusion induced a decrease in the ratio between branched chain amino acids and aromatic amino acids, increased unidirectional phenylalanine uptake, and increased net brain glutamine release. Cerebral proteolysis is suggested to play a role, but the question is whether this is the case and why this would happen.
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spelling pubmed-29116892011-05-14 Does proteolysis explain glutamine release from the septic brain? Dejong, Cornelius HC Olde Damink, Steven WM Crit Care Commentary Berg and colleagues report on amino acid exchange across the human brain during endotoxin infusion. Lipopolysaccharide infusion induced a decrease in the ratio between branched chain amino acids and aromatic amino acids, increased unidirectional phenylalanine uptake, and increased net brain glutamine release. Cerebral proteolysis is suggested to play a role, but the question is whether this is the case and why this would happen. BioMed Central 2010 2010-05-14 /pmc/articles/PMC2911689/ /pubmed/20497607 http://dx.doi.org/10.1186/cc8971 Text en Copyright ©2010 BioMed Central Ltd
spellingShingle Commentary
Dejong, Cornelius HC
Olde Damink, Steven WM
Does proteolysis explain glutamine release from the septic brain?
title Does proteolysis explain glutamine release from the septic brain?
title_full Does proteolysis explain glutamine release from the septic brain?
title_fullStr Does proteolysis explain glutamine release from the septic brain?
title_full_unstemmed Does proteolysis explain glutamine release from the septic brain?
title_short Does proteolysis explain glutamine release from the septic brain?
title_sort does proteolysis explain glutamine release from the septic brain?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911689/
https://www.ncbi.nlm.nih.gov/pubmed/20497607
http://dx.doi.org/10.1186/cc8971
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