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Does proteolysis explain glutamine release from the septic brain?
Berg and colleagues report on amino acid exchange across the human brain during endotoxin infusion. Lipopolysaccharide infusion induced a decrease in the ratio between branched chain amino acids and aromatic amino acids, increased unidirectional phenylalanine uptake, and increased net brain glutamin...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911689/ https://www.ncbi.nlm.nih.gov/pubmed/20497607 http://dx.doi.org/10.1186/cc8971 |
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author | Dejong, Cornelius HC Olde Damink, Steven WM |
author_facet | Dejong, Cornelius HC Olde Damink, Steven WM |
author_sort | Dejong, Cornelius HC |
collection | PubMed |
description | Berg and colleagues report on amino acid exchange across the human brain during endotoxin infusion. Lipopolysaccharide infusion induced a decrease in the ratio between branched chain amino acids and aromatic amino acids, increased unidirectional phenylalanine uptake, and increased net brain glutamine release. Cerebral proteolysis is suggested to play a role, but the question is whether this is the case and why this would happen. |
format | Text |
id | pubmed-2911689 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29116892011-05-14 Does proteolysis explain glutamine release from the septic brain? Dejong, Cornelius HC Olde Damink, Steven WM Crit Care Commentary Berg and colleagues report on amino acid exchange across the human brain during endotoxin infusion. Lipopolysaccharide infusion induced a decrease in the ratio between branched chain amino acids and aromatic amino acids, increased unidirectional phenylalanine uptake, and increased net brain glutamine release. Cerebral proteolysis is suggested to play a role, but the question is whether this is the case and why this would happen. BioMed Central 2010 2010-05-14 /pmc/articles/PMC2911689/ /pubmed/20497607 http://dx.doi.org/10.1186/cc8971 Text en Copyright ©2010 BioMed Central Ltd |
spellingShingle | Commentary Dejong, Cornelius HC Olde Damink, Steven WM Does proteolysis explain glutamine release from the septic brain? |
title | Does proteolysis explain glutamine release from the septic brain? |
title_full | Does proteolysis explain glutamine release from the septic brain? |
title_fullStr | Does proteolysis explain glutamine release from the septic brain? |
title_full_unstemmed | Does proteolysis explain glutamine release from the septic brain? |
title_short | Does proteolysis explain glutamine release from the septic brain? |
title_sort | does proteolysis explain glutamine release from the septic brain? |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911689/ https://www.ncbi.nlm.nih.gov/pubmed/20497607 http://dx.doi.org/10.1186/cc8971 |
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