Cargando…

Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity

INTRODUCTION: Angiopoietin-2 (ang-2), an angiogenic peptide released by endothelial cell Weibel-Palade bodies (WPBs), increases endothelial activation and vascular permeability. Ang-2 is raised in severe sepsis but the mechanisms underlying this are not known. Nitric oxide (NO) inhibits WPB exocytos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Davis, Joshua S, Yeo, Tsin W, Piera, Kim A, Woodberry, Tonia, Celermajer, David S, Stephens, Dianne P, Anstey, Nicholas M
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911723/ https://www.ncbi.nlm.nih.gov/pubmed/20482750 http://dx.doi.org/10.1186/cc9020

Ejemplares similares

An Observational Cohort Study of the Kynurenine to Tryptophan Ratio in Sepsis: Association with Impaired Immune and Microvascular Function
por: Darcy, Christabelle J., et al.
Publicado: (2011)

Asymmetric Dimethylarginine, Endothelial Nitric Oxide Bioavailability and Mortality in Sepsis
por: Davis, Joshua S., et al.
Publicado: (2011)

Sepsis-associated microvascular dysfunction measured by peripheral arterial tonometry: an observational study
por: Davis, Joshua S, et al.
Publicado: (2009)

Finger reactive hyperaemia to measure endothelial function in sepsis and health (the FRESH study)
por: Davis, JS, et al.
Publicado: (2008)

Ex-vivo changes in amino acid concentrations from blood stored at room temperature or on ice: implications for arginine and taurine measurements
por: Davis, Joshua S, et al.
Publicado: (2009)

Parasite Biomass-Related Inflammation, Endothelial Activation, Microvascular Dysfunction and Disease Severity in Vivax Malaria
por: Barber, Bridget E., et al.
Publicado: (2015)

Intravascular haemolysis in severe Plasmodium knowlesi malaria: association with endothelial activation, microvascular dysfunction, and acute kidney injury
por: Barber, Bridget E., et al.
Publicado: (2018)

A clinicopathological correlation of the expression of the angiopoietin-Tie-2 receptor pathway in the brain of adults with Plasmodium falciparum malaria
por: Prapansilp, Panote, et al.
Publicado: (2013)

Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis
por: Alfieri, Alessio, et al.
Publicado: (2012)

Neutrophils with myeloid derived suppressor function deplete arginine and constrain T cell function in septic shock patients
por: Darcy, Christabelle J, et al.
Publicado: (2014)

Parasite-Dependent Expansion of TNF Receptor II–Positive Regulatory T Cells with Enhanced Suppressive Activity in Adults with Severe Malaria
por: Minigo, Gabriela, et al.
Publicado: (2009)

Decreased Microvascular Function in Tanzanian Children With Severe and Uncomplicated Falciparum Malaria
por: Yeo, Tsin W., et al.
Publicado: (2017)

Impaired nitric oxide bioavailability and l-arginine–reversible endothelial dysfunction in adults with falciparum malaria
por: Yeo, Tsin W., et al.
Publicado: (2007)

Angiopoietin-1, Angiopoietin-2 and Bicarbonate as Diagnostic Biomarkers in Children with Severe Sepsis
por: Wang, Kun, et al.
Publicado: (2014)

Increased Asymmetric Dimethylarginine in Severe Falciparum Malaria: Association with Impaired Nitric Oxide Bioavailability and Fatal Outcome
por: Yeo, Tsin W., et al.
Publicado: (2010)

Correction: Increased Asymmetric Dimethylarginine in Severe Falciparum Malaria: Association with Impaired Nitric Oxide Bioavailability and Fatal Outcome
por: Yeo, Tsin W., et al.
Publicado: (2010)

Prognostic significance of the angiopoietin-2/angiopoietin-1 and angiopoietin-1/Tie-2 ratios for early sepsis in an emergency department
por: Fang, Yingying, et al.
Publicado: (2015)

Bench-to-bedside review: Microvascular dysfunction in sepsis –hemodynamics, oxygen transport, and nitric oxide
por: Bateman, Ryon M, et al.
Publicado: (2003)

Impaired Systemic Tetrahydrobiopterin Bioavailability and Increased Dihydrobiopterin in Adult Falciparum Malaria: Association with Disease Severity, Impaired Microvascular Function and Increased Endothelial Activation
por: Yeo, Tsin W., et al.
Publicado: (2015)

Asymmetric Dimethylarginine in Adult Falciparum Malaria: Relationships With Disease Severity, Antimalarial Treatment, Hemolysis, and Inflammation
por: Barber, Bridget E., et al.
Publicado: (2016)

Dysregulation of the angiopoietin–Tie-2 axis in sepsis and ARDS
por: Parikh, Samir M
Publicado: (2013)

Reactive oxygen and nitrogen species in sepsis-induced hepatic microvascular dysfunction
por: Singer, Georg, et al.
Publicado: (2012)

Flunarizine suppresses endothelial Angiopoietin-2 in a calcium - dependent fashion in sepsis
por: Retzlaff, Jennifer, et al.
Publicado: (2017)

Does low angiopoietin-1 predict adverse outcome in sepsis?
por: David, Sascha, et al.
Publicado: (2010)

A plethora of angiopoietin-2 effects during clinical sepsis
por: Amerongen, Geerten P van Nieuw, et al.
Publicado: (2010)

The renal angiopoietin/Tie2 system in lethal human sepsis
por: Aslan, Adnan, et al.
Publicado: (2014)

Hypogammaglobulinemia in sepsis is not correlated to high circulating angiopoietin-2 levels
por: Kovačič, U, et al.
Publicado: (2013)

Opposing Effects of the Angiopoietins on the Thrombin-Induced Permeability of Human Pulmonary Microvascular Endothelial Cells
por: van der Heijden, Melanie, et al.
Publicado: (2011)

Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx
por: Salmon, Andrew H.J., et al.
Publicado: (2009)

OR14-6 The Role of the Angiopoietin-Tie2 Pathway in Microvascular Complications of Diabetes Mellitus
por: Brigell, Mitchell, et al.
Publicado: (2019)

Endothelial glycocalyx degradation and disease severity in Plasmodium vivax and Plasmodium knowlesi malaria
por: Barber, Bridget E., et al.
Publicado: (2021)

Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria
por: Woodberry, Tonia, et al.
Publicado: (2009)

Monocyte polarization in children with falciparum malaria: relationship to nitric oxide insufficiency and disease severity
por: Weinberg, J. Brice, et al.
Publicado: (2016)

Systemic Angiopoietin-1/2 Dysregulation in Pediatric Sepsis and Septic Shock
por: Melendez, Elliot, et al.
Publicado: (2019)

Effect of angiopoietin-like protein 4 on rat pulmonary microvascular endothelial cells exposed to LPS
por: WANG, YUXI, et al.
Publicado: (2013)

Early Systemic Microvascular Damage in Pigs with Atherogenic Diabetes Mellitus Coincides with Renal Angiopoietin Dysbalance
por: Khairoun, Meriem, et al.
Publicado: (2015)

Plasmodium falciparum Activates CD16(+) Dendritic Cells to Produce Tumor Necrosis Factor and Interleukin-10 in Subpatent Malaria
por: Loughland, Jessica R, et al.
Publicado: (2019)

Limitations of microscopy to differentiate Plasmodium species in a region co-endemic for Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi
por: Barber, Bridget E, et al.
Publicado: (2013)

Intravascular haemolysis with haemoglobinuria in a splenectomized patient with severe Plasmodium knowlesi malaria
por: Barber, Bridget E., et al.
Publicado: (2016)

Anti-angiogenic Targets: Angiopoietin and Angiopoietin Receptors
por: Kiss, Elina A., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_4as49cpkq74jlclj6ckgoiprh0