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The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic information
The human oral microbiome is the most studied human microflora, but 53% of the species have not yet been validly named and 35% remain uncultivated. The uncultivated taxa are known primarily from 16S rRNA sequence information. Sequence information tied solely to obscure isolate or clone numbers, and...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Oxford University Press
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911848/ https://www.ncbi.nlm.nih.gov/pubmed/20624719 http://dx.doi.org/10.1093/database/baq013 |
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author | Chen, Tsute Yu, Wen-Han Izard, Jacques Baranova, Oxana V. Lakshmanan, Abirami Dewhirst, Floyd E. |
author_facet | Chen, Tsute Yu, Wen-Han Izard, Jacques Baranova, Oxana V. Lakshmanan, Abirami Dewhirst, Floyd E. |
author_sort | Chen, Tsute |
collection | PubMed |
description | The human oral microbiome is the most studied human microflora, but 53% of the species have not yet been validly named and 35% remain uncultivated. The uncultivated taxa are known primarily from 16S rRNA sequence information. Sequence information tied solely to obscure isolate or clone numbers, and usually lacking accurate phylogenetic placement, is a major impediment to working with human oral microbiome data. The goal of creating the Human Oral Microbiome Database (HOMD) is to provide the scientific community with a body site-specific comprehensive database for the more than 600 prokaryote species that are present in the human oral cavity based on a curated 16S rRNA gene-based provisional naming scheme. Currently, two primary types of information are provided in HOMD—taxonomic and genomic. Named oral species and taxa identified from 16S rRNA gene sequence analysis of oral isolates and cloning studies were placed into defined 16S rRNA phylotypes and each given unique Human Oral Taxon (HOT) number. The HOT interlinks phenotypic, phylogenetic, genomic, clinical and bibliographic information for each taxon. A BLAST search tool is provided to match user 16S rRNA gene sequences to a curated, full length, 16S rRNA gene reference data set. For genomic analysis, HOMD provides comprehensive set of analysis tools and maintains frequently updated annotations for all the human oral microbial genomes that have been sequenced and publicly released. Oral bacterial genome sequences, determined as part of the Human Microbiome Project, are being added to the HOMD as they become available. We provide HOMD as a conceptual model for the presentation of microbiome data for other human body sites. Database URL: http://www.homd.org |
format | Text |
id | pubmed-2911848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-29118482010-07-30 The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic information Chen, Tsute Yu, Wen-Han Izard, Jacques Baranova, Oxana V. Lakshmanan, Abirami Dewhirst, Floyd E. Database (Oxford) Original Article The human oral microbiome is the most studied human microflora, but 53% of the species have not yet been validly named and 35% remain uncultivated. The uncultivated taxa are known primarily from 16S rRNA sequence information. Sequence information tied solely to obscure isolate or clone numbers, and usually lacking accurate phylogenetic placement, is a major impediment to working with human oral microbiome data. The goal of creating the Human Oral Microbiome Database (HOMD) is to provide the scientific community with a body site-specific comprehensive database for the more than 600 prokaryote species that are present in the human oral cavity based on a curated 16S rRNA gene-based provisional naming scheme. Currently, two primary types of information are provided in HOMD—taxonomic and genomic. Named oral species and taxa identified from 16S rRNA gene sequence analysis of oral isolates and cloning studies were placed into defined 16S rRNA phylotypes and each given unique Human Oral Taxon (HOT) number. The HOT interlinks phenotypic, phylogenetic, genomic, clinical and bibliographic information for each taxon. A BLAST search tool is provided to match user 16S rRNA gene sequences to a curated, full length, 16S rRNA gene reference data set. For genomic analysis, HOMD provides comprehensive set of analysis tools and maintains frequently updated annotations for all the human oral microbial genomes that have been sequenced and publicly released. Oral bacterial genome sequences, determined as part of the Human Microbiome Project, are being added to the HOMD as they become available. We provide HOMD as a conceptual model for the presentation of microbiome data for other human body sites. Database URL: http://www.homd.org Oxford University Press 2010-07-06 /pmc/articles/PMC2911848/ /pubmed/20624719 http://dx.doi.org/10.1093/database/baq013 Text en © The Author(s) 2010. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/2.5 This is Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Chen, Tsute Yu, Wen-Han Izard, Jacques Baranova, Oxana V. Lakshmanan, Abirami Dewhirst, Floyd E. The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic information |
title | The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic information |
title_full | The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic information |
title_fullStr | The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic information |
title_full_unstemmed | The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic information |
title_short | The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic information |
title_sort | human oral microbiome database: a web accessible resource for investigating oral microbe taxonomic and genomic information |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911848/ https://www.ncbi.nlm.nih.gov/pubmed/20624719 http://dx.doi.org/10.1093/database/baq013 |
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