Inhibitor of IκB kinase activity, BAY 11-7082, interferes with interferon regulatory factor 7 nuclear translocation and type I interferon production by plasmacytoid dendritic cells

INTRODUCTION: Plasmacytoid dendritic cells (pDCs) play not only a central role in the antiviral immune response in innate host defense, but also a pathogenic role in the development of the autoimmune process by their ability to produce robust amounts of type I interferons (IFNs), through sensing nuc...

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Detalles Bibliográficos
Autores principales: Miyamoto, Rie, Ito, Tomoki, Nomura, Shosaku, Amakawa, Ryuichi, Amuro, Hideki, Katashiba, Yuichi, Ogata, Makoto, Murakami, Naoko, Shimamoto, Keiko, Yamazaki, Chihiro, Hoshino, Katsuaki, Kaisho, Tsuneyasu, Fukuhara, Shirou
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911871/
https://www.ncbi.nlm.nih.gov/pubmed/20470398
http://dx.doi.org/10.1186/ar3014

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