Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor, on osteoclasts and collagen-induced arthritis in mice

INTRODUCTION: Targeting joint destruction induced by osteoclasts (OCs) is critical for management of patients with rheumatoid arthritis (RA). Since phosphoinositide 3-kinase (PI3-K) plays a critical role in osteoclastogenesis and bone resorption, we examined the effects of ZSTK474, a novel phosphoin...

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Detalles Bibliográficos
Autores principales: Toyama, Shoko, Tamura, Naoto, Haruta, Kazuhiko, Karakida, Takeo, Mori, Shigeyuki, Watanabe, Tetsuo, Yamori, Takao, Takasaki, Yoshinari
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911876/
https://www.ncbi.nlm.nih.gov/pubmed/20482767
http://dx.doi.org/10.1186/ar3019

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