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Time to achieve remission determines time to be in remission

INTRODUCTION: Though remission is currently a treatment goal in patients with rheumatoid arthritis (RA), the number of patients who achieve and sustain remission in daily practice is still small. It is suggested that early remission will be associated with sustainability of remission. The aim was to...

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Autores principales: Schipper, Lydia G, Fransen, Jaap, den Broeder, Alfons A, Van Riel, Piet LCM
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911884/
https://www.ncbi.nlm.nih.gov/pubmed/20487520
http://dx.doi.org/10.1186/ar3027
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author Schipper, Lydia G
Fransen, Jaap
den Broeder, Alfons A
Van Riel, Piet LCM
author_facet Schipper, Lydia G
Fransen, Jaap
den Broeder, Alfons A
Van Riel, Piet LCM
author_sort Schipper, Lydia G
collection PubMed
description INTRODUCTION: Though remission is currently a treatment goal in patients with rheumatoid arthritis (RA), the number of patients who achieve and sustain remission in daily practice is still small. It is suggested that early remission will be associated with sustainability of remission. The aim was to study the association between time-to-remission and sustainability of remission in a cohort of early RA patients treated according to daily practice. METHODS: For this study, three-year follow-up data were used from the Nijmegen RA Inception Cohort of patients included between 1985 and 2005 (N = 753). Patients were included upon diagnosis (ACR criteria), were systematically evaluated at three-monthly visits and treated according to daily practice. Remission was defined according to the Disease Activity Score (DAS) <1.6 and the ACR remission criteria. Remission of at least 6 months duration was regarded as sustained remission. Predictors for time-to-remission were identified by Cox-regression analyses. The relation between time-to-remission and sustained remission was analyzed using longitudinal binary regression. RESULTS: N = 398 (52%) patients achieved remission with a median time-to-remission of 12 months. Male gender, younger age and low DAS at baseline were predictive to reach remission rapidly. There were n = 142 (36%) patients experiencing sustained remission, which was determined by a shorter time-to-remission only. The relationship between time-to-remission and sustained remission was described by a significant odds ratio (1.11) (1.10 to 1.12-95% CI) that was constant over the whole period 1985 to 2005. Results obtained with the ACR remission criteria were similar. CONCLUSIONS: A shorter time-to-remission is related to sustainability of remission, supporting striving for early remission in patients with RA.
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spelling pubmed-29118842010-07-29 Time to achieve remission determines time to be in remission Schipper, Lydia G Fransen, Jaap den Broeder, Alfons A Van Riel, Piet LCM Arthritis Res Ther Research Article INTRODUCTION: Though remission is currently a treatment goal in patients with rheumatoid arthritis (RA), the number of patients who achieve and sustain remission in daily practice is still small. It is suggested that early remission will be associated with sustainability of remission. The aim was to study the association between time-to-remission and sustainability of remission in a cohort of early RA patients treated according to daily practice. METHODS: For this study, three-year follow-up data were used from the Nijmegen RA Inception Cohort of patients included between 1985 and 2005 (N = 753). Patients were included upon diagnosis (ACR criteria), were systematically evaluated at three-monthly visits and treated according to daily practice. Remission was defined according to the Disease Activity Score (DAS) <1.6 and the ACR remission criteria. Remission of at least 6 months duration was regarded as sustained remission. Predictors for time-to-remission were identified by Cox-regression analyses. The relation between time-to-remission and sustained remission was analyzed using longitudinal binary regression. RESULTS: N = 398 (52%) patients achieved remission with a median time-to-remission of 12 months. Male gender, younger age and low DAS at baseline were predictive to reach remission rapidly. There were n = 142 (36%) patients experiencing sustained remission, which was determined by a shorter time-to-remission only. The relationship between time-to-remission and sustained remission was described by a significant odds ratio (1.11) (1.10 to 1.12-95% CI) that was constant over the whole period 1985 to 2005. Results obtained with the ACR remission criteria were similar. CONCLUSIONS: A shorter time-to-remission is related to sustainability of remission, supporting striving for early remission in patients with RA. BioMed Central 2010 2010-05-20 /pmc/articles/PMC2911884/ /pubmed/20487520 http://dx.doi.org/10.1186/ar3027 Text en Copyright ©2010 Schipper et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Schipper, Lydia G
Fransen, Jaap
den Broeder, Alfons A
Van Riel, Piet LCM
Time to achieve remission determines time to be in remission
title Time to achieve remission determines time to be in remission
title_full Time to achieve remission determines time to be in remission
title_fullStr Time to achieve remission determines time to be in remission
title_full_unstemmed Time to achieve remission determines time to be in remission
title_short Time to achieve remission determines time to be in remission
title_sort time to achieve remission determines time to be in remission
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911884/
https://www.ncbi.nlm.nih.gov/pubmed/20487520
http://dx.doi.org/10.1186/ar3027
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