Cargando…

The Nuclear Receptor PPARγ as a Therapeutic Target for Cerebrovascular and Brain Dysfunction in Alzheimer's Disease

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear transcription factors that regulate peripheral lipid and glucose metabolism. Three subtypes make up the PPAR family (α, γ, β/δ), and synthetic ligands for PPARα (fibrates) and PPARγ (Thiazolidinediones, TZDs) are curren...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nicolakakis, Nektaria, Hamel, Edith
Formato:	Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2010
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912024/ https://www.ncbi.nlm.nih.gov/pubmed/20725514 http://dx.doi.org/10.3389/fnagi.2010.00021

Ejemplares similares

The Nuclear Hormone Receptor PPAR(γ) as a Therapeutic Target in Major Diseases
por: Schmidt, Martina Victoria, et al.
Publicado: (2010)

APOE and Alzheimer’s Disease: Neuroimaging of Metabolic and Cerebrovascular Dysfunction
por: Brandon, Jason A., et al.
Publicado: (2018)

Nuclear receptor corepressors and PPARγ
por: Cohen, Ronald N.
Publicado: (2006)

Therapeutic Advantages of Dual Targeting of PPAR-δ and PPAR-γ in an Experimental Model of Sporadic Alzheimer’s Disease
por: Reich, D, et al.
Publicado: (2018)

P2X7 Receptors as a Therapeutic Target in Cerebrovascular Diseases
por: Cisneros-Mejorado, Abraham J., et al.
Publicado: (2020)

Pericytes in Cerebrovascular Diseases: An Emerging Therapeutic Target
por: Su, Xiaojuan, et al.
Publicado: (2019)

Cognitive and cerebrovascular improvements following kinin B(1) receptor blockade in Alzheimer’s disease mice
por: Lacoste, Baptiste, et al.
Publicado: (2013)

Allosteric Pathways in the PPARγ-RXRα nuclear receptor complex
por: Ricci, Clarisse G., et al.
Publicado: (2016)

Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ
por: Shang, Jinsai, et al.
Publicado: (2018)

Pioglitazone Reduces β Amyloid Levels via Inhibition of PPARγ Phosphorylation in a Neuronal Model of Alzheimer’s Disease
por: Quan, Qiankun, et al.
Publicado: (2019)

Nuclear peroxisome proliferator activated receptor-gamma (PPARγ) as a therapeutic target to treat neurodegeneration and dependence elicited by drugs of abuse
por: Ciccocioppo, Roberto, et al.
Publicado: (2020)

PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s
por: Corona, Juan Carlos, et al.
Publicado: (2014)

PPARγ as a Novel Therapeutic Target in Lung Cancer
por: Reddy, Aravind T., et al.
Publicado: (2016)

Imaging of cerebrovascular pathology in animal models of Alzheimer's disease
por: Klohs, Jan, et al.
Publicado: (2014)

Neurovascular crosstalk and cerebrovascular alterations: an underestimated therapeutic target in autism spectrum disorders
por: Wang, Yiran, et al.
Publicado: (2023)

Nuclear Receptor Cofactors in PPARγ-Mediated Adipogenesis and Adipocyte Energy Metabolism
por: Powell, Emily, et al.
Publicado: (2007)

Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism
por: Lizcano, Fernando, et al.
Publicado: (2013)

Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ
por: Heidari, Zahra, et al.
Publicado: (2019)

Dysfunction of Cerebrovascular Endothelial Cells: Prelude to Vascular Dementia
por: Wang, Feixue, et al.
Publicado: (2018)

Pioglitazone Improves Reversal Learning and Exerts Mixed Cerebrovascular Effects in a Mouse Model of Alzheimer’s Disease with Combined Amyloid-β and Cerebrovascular Pathology
por: Papadopoulos, Panayiota, et al.
Publicado: (2013)

Cerebrovascular-Reactivity Mapping Using MRI: Considerations for Alzheimer’s Disease
por: Chen, J. J.
Publicado: (2018)

Potential Therapeutic Targets for PPARγ after Spinal Cord Injury
por: McTigue, Dana M.
Publicado: (2008)

Therapeutic Opportunities for Intestinal Angioectasia‐ Targeting PPARγ and Oxidative Stress
por: Sarangdhar, Mayur, et al.
Publicado: (2020)

Erratum: “The Role of Dietary Phytoestrogens and the Nuclear Receptor PPARγ in Adipogenesis: An in Vitro Study”
por: Hall, Julie M., et al.
Publicado: (2019)

PPARβ/δ and PPARγ maintain undifferentiated phenotypes of mouse adult neural precursor cells from the subventricular zone
por: Bernal, Carolina, et al.
Publicado: (2015)

Is peroxisome proliferator-activated receptor gamma (PPARγ) a therapeutic target for the treatment of pulmonary hypertension?
por: Green, David E., et al.
Publicado: (2011)

PPARγ Regulates Triclosan Induced Placental Dysfunction
por: Li, Jing, et al.
Publicado: (2021)

PPAR-γ: Therapeutic Potential for Multiple Sclerosis
por: Drew, Paul D., et al.
Publicado: (2008)

Therapeutic Potential of PPARγ Activation in Stroke
por: Vemuganti, Raghu
Publicado: (2008)

Therapeutic Implications of PPARγ in Human Osteosarcoma
por: Wagner, Eric R., et al.
Publicado: (2010)

Therapeutic Implications of PPARγ in Cardiovascular Diseases
por: Hasegawa, Hiroshi, et al.
Publicado: (2010)

Nuclear Peroxisome Proliferator-Activated Receptors (PPARs) as Therapeutic Targets of Resveratrol for Autism Spectrum Disorder
por: Barone, Rita, et al.
Publicado: (2019)

Nuclear Receptor PPARα as a Therapeutic Target in Diseases Associated with Lipid Metabolism Disorders
por: Hu, Ping, et al.
Publicado: (2023)

Blood-brain barrier dysfunction and Alzheimer’s disease: associations, pathogenic mechanisms, and therapeutic potential
por: Chen, Yanting, et al.
Publicado: (2023)

Editorial: The Neurovascular Unit as a Potential Biomarker and Therapeutic Target in Cerebrovascular Disease
por: Nizari, Shereen, et al.
Publicado: (2022)

Cerebrovascular Resistance: The Basis of Cerebrovascular Reactivity
por: Duffin, James, et al.
Publicado: (2018)

Direct Oral Anticoagulants (DOACs) for Therapeutic Targeting of Thrombin, a Key Mediator of Cerebrovascular and Neuronal Dysfunction in Alzheimer’s Disease
por: Grossmann, Klaus
Publicado: (2022)

Alzheimer’s disease: relevant molecular and physiopathological events affecting amyloid-β brain balance and the putative role of PPARs
por: Zolezzi, Juan M., et al.
Publicado: (2014)

PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease
por: Corona, Juan Carlos, et al.
Publicado: (2016)

Systemic infection exacerbates cerebrovascular dysfunction in Alzheimer’s disease
por: Asby, Daniel, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_msngvftr77evn2a5lpq2midfiu