Cargando…

ROS accumulation and IGF-IR inhibition contribute to fenofibrate/PPARα -mediated inhibition of Glioma cell motility in vitro

BACKGROUND: Glioblastomas are characterized by rapid cell growth, aggressive CNS infiltration, and are resistant to all known anticancer regimens. Recent studies indicate that fibrates and statins possess anticancer potential. Fenofibrate is a potent agonist of peroxisome proliferator activated rece...

Descripción completa

Detalles Bibliográficos
Autores principales:	Drukala, Justyna, Urbanska, Katarzyna, Wilk, Anna, Grabacka, Maja, Wybieralska, Ewa, Del Valle, Luis, Madeja, Zbigniew, Reiss, Krzysztof
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912247/ https://www.ncbi.nlm.nih.gov/pubmed/20569465 http://dx.doi.org/10.1186/1476-4598-9-159

Ejemplares similares

Solute-dependent activation of cell motility in strongly hypertonic solutions in Dictyostelium discoideum, human melanoma HTB-140 cells and walker 256 carcinosarcoma cells
por: Korohoda, Włodzimierz, et al.
Publicado: (2011)

Fenofibrate Induces Ketone Body Production in Melanoma and Glioblastoma Cells
por: Grabacka, Maja M., et al.
Publicado: (2016)

Anticancer Properties of PPARα-Effects on Cellular Metabolism and Inflammation
por: Grabacka, Maja, et al.
Publicado: (2008)

Ascorbic acid inhibits the migration of walker 256 carcinosarcoma cells
por: Wybieralska, Ewa, et al.
Publicado: (2007)

Regulation of Ketone Body Metabolism and the Role of PPARα
por: Grabacka, Maja, et al.
Publicado: (2016)

IGF-IR dependent expression of Survivin is required for T-Antigen mediated Protection from Apoptosis and Proliferation of Neural Progenitors
por: Gualco, Elisa, et al.
Publicado: (2009)

The PPARα Agonist Fenofibrate Reduces Prepulse Inhibition Disruption in a Neurodevelopmental Model of Schizophrenia
por: Rolland, Benjamin, et al.
Publicado: (2012)

Fenofibrate Interferes with the Diapedesis of Lung Adenocarcinoma Cells through the Interference with Cx43/EGF-Dependent Intercellular Signaling
por: Piwowarczyk, Katarzyna, et al.
Publicado: (2018)

Long-Term Fenofibrate Treatment Stimulates the Phenotypic Microevolution of Prostate Cancer Cells In Vitro
por: Warzecha, Karolina W., et al.
Publicado: (2022)

The Role of PPAR Alpha in the Modulation of Innate Immunity
por: Grabacka, Maja, et al.
Publicado: (2021)

Apigenin inhibits growth and motility but increases gap junctional coupling intensity in rat prostate carcinoma (MAT-LyLu) cell populations
por: Czernik, Marta, et al.
Publicado: (2008)

Poly(L-lactide-co-glycolide) thin films can act as autologous cell carriers for skin tissue engineering
por: Zuber, Aleksandra, et al.
Publicado: (2014)

The PPARα Regulation of the Gut Physiology in Regard to Interaction with Microbiota, Intestinal Immunity, Metabolism, and Permeability
por: Grabacka, Maja, et al.
Publicado: (2022)

Effects and mechanisms of PPARα activator fenofibrate on myocardial remodelling in hypertension
por: Li, Chuan-Bao, et al.
Publicado: (2009)

Novel role of cannabinoid receptor 2 in inhibiting EGF/EGFR and IGF-I/IGF-IR pathways in breast cancer
por: Elbaz, Mohamad, et al.
Publicado: (2016)

Rosiglitazone Inhibits Adrenocortical Cancer Cell Proliferation by Interfering with the IGF-IR Intracellular Signaling
por: Cantini, Giulia, et al.
Publicado: (2008)

Fenofibrate Augments the Sensitivity of Drug-Resistant Prostate Cancer Cells to Docetaxel
por: Luty, Marcin, et al.
Publicado: (2019)

Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro
por: Zhou, Zhou, et al.
Publicado: (2012)

Genistein inhibits the contact-stimulated migration of prostate cancer cells
por: Miękus, Katarzyna, et al.
Publicado: (2007)

Dual inhibition of IGF-IR and ALK as an effective strategy to eradicate NPM-ALK(+) T-cell lymphoma
por: George, Bhawana, et al.
Publicado: (2019)

IGF-IR promotes clonal cell proliferation in myelodysplastic syndromes via inhibition of the MAPK pathway
por: He, Qi, et al.
Publicado: (2020)

PPARγ inhibition regulates the cell cycle, proliferation and motility of bladder cancer cells
por: Cheng, Songtao, et al.
Publicado: (2019)

Adipose-Derived Stromal Cells Seeded on Integra(®) Dermal Regeneration Template Improve Post-Burn Wound Reconstruction
por: Piejko, Marcin, et al.
Publicado: (2020)

DU-145 prostate carcinoma cells that selectively transmigrate narrow obstacles express elevated levels of Cx43
por: Szpak, Katarzyna, et al.
Publicado: (2011)

IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights
por: Li, Heming, et al.
Publicado: (2017)

Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)α agonist fenofibrate and the PPARγ agonist pioglitazone
por: Syversen, Unni, et al.
Publicado: (2009)

In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer
por: Saidi, Samir A, et al.
Publicado: (2006)

The whole transcriptome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice
por: de la Rosa Rodriguez, Montserrat A., et al.
Publicado: (2018)

PPAR-Alpha Agonist Fenofibrate Combined with Octreotide Acetate in the Treatment of Acute Hyperlipidemia Pancreatitis
por: Bao, Wen, et al.
Publicado: (2021)

PPAR-α Agonist Fenofibrate Prevented Diabetic Nephropathy by Inhibiting M1 Macrophages via Improving Endothelial Cell Function in db/db Mice
por: Feng, Xiaomeng, et al.
Publicado: (2021)

Human pancreatic cancer stem cells are sensitive to dual inhibition of IGF-IR and ErbB receptors
por: Urtasun, Nerea, et al.
Publicado: (2015)

Crk II silencing down-regulates IGF-IR and inhibits migration and invasion of prostate cancer cells
por: Dhupkar, Pooja, et al.
Publicado: (2016)

Correction: Dual inhibition of IGF-IR and ALK as an effective strategy to eradicate NPM-ALK(+) T-cell lymphoma
por: George, Bhawana, et al.
Publicado: (2023)

Rapamycin Inhibits IGF-1 Stimulated Cell Motility through PP2A Pathway
por: Liu, Lei, et al.
Publicado: (2010)

Fenofibrate Reduces the Asthma-Related Fibroblast-To-Myofibroblast Transition by TGF-Β/Smad2/3 Signaling Attenuation and Connexin 43-Dependent Phenotype Destabilization
por: Paw, Milena, et al.
Publicado: (2018)

Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis
por: Beneit, N., et al.
Publicado: (2016)

Chemically Modified Variants of Fenofibrate with Antiglioblastoma Potential()()
por: Stalinska, J., et al.
Publicado: (2019)

CD44 (+) cells determine fenofibrate‐induced microevolution of drug‐resistance in prostate cancer cell populations
por: Wróbel, Tomasz, et al.
Publicado: (2020)

Novel cross-talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses
por: Malaguarnera, Roberta, et al.
Publicado: (2015)

HMGB1 Is Involved in the Protective Effect of the PPARα Agonist Fenofibrate against Cardiac Hypertrophy
por: Jia, Zhankui, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_dtmp440pom1hk2act1sjpl6f82