The 4q12 Amplicon in Malignant Peripheral Nerve Sheath Tumors: Consequences on Gene Expression and Implications for Sunitinib Treatment

BACKGROUND: Malignant peripheral nerve sheath tumors (MPNST) are highly aggressive tumors which originate from Schwann cells and develop in about 10% of neurofibromatosis type 1 (NF1) patients. The five year survival rate is poor and more effective therapies are needed. Sunitinib is a drug targeting...

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Detalles Bibliográficos
Autores principales: Zietsch, Jan, Ziegenhagen, Nicolas, Heppner, Frank L., Reuss, David, von Deimling, Andreas, Holtkamp, Nikola
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912277/
https://www.ncbi.nlm.nih.gov/pubmed/20686603
http://dx.doi.org/10.1371/journal.pone.0011858

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