A study of long-term potentiation in transgenic mice over-expressing mutant forms of both amyloid precursor protein and presenilin-1

Synaptic transmission and long-term potentiation (LTP) in the CA1 region of hippocampal slices have been studied during ageing of a double transgenic mouse strain relevant to early-onset familial Alzheimer's disease (AD). This strain, which over-expresses both the 695 amino acid isoform of huma...

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Detalles Bibliográficos
Autores principales: Fitzjohn, Stephen M, Kuenzi, Frederick, Morton, Robin A, Rosahl, Thomas W, Lewis, Huw, Smith, David, Seabrook, Guy R, Collingridge, Graham L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912307/
https://www.ncbi.nlm.nih.gov/pubmed/20630068
http://dx.doi.org/10.1186/1756-6606-3-21

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