Investigating the synchronization of hippocampal neural network in response to acute nicotine exposure

Previous studies suggested that γ oscillations in the brain are associated with higher order cognitive function including selective visual attention, motor task planning, sensory perception, working memory and dreaming REM sleep. These oscillations are mainly observed in cortical regions and also oc...

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Autores principales: Akkurt, David, Akay, Yasemin M, Akay, Metin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912318/
https://www.ncbi.nlm.nih.gov/pubmed/20626893
http://dx.doi.org/10.1186/1743-0003-7-31
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author Akkurt, David
Akay, Yasemin M
Akay, Metin
author_facet Akkurt, David
Akay, Yasemin M
Akay, Metin
author_sort Akkurt, David
collection PubMed
description Previous studies suggested that γ oscillations in the brain are associated with higher order cognitive function including selective visual attention, motor task planning, sensory perception, working memory and dreaming REM sleep. These oscillations are mainly observed in cortical regions and also occur in neocortical and subcortical areas and the hippocampus. In this paper, we investigate the influence of acute exposure to nicotine on the complexity of hippocampal γ oscillations. Using the approximate entropy method, the influence of acute nicotine exposure on the hippocampal γ oscillations was investigated. The hippocampal γ oscillations have been generated in response to the 100 Hz stimulus and isolated using the visual inspection and spectral analysis method. Our central hypothesis is that acute exposure to nicotine significantly reduces the complexity of hippocampal γ oscillations. We used brain-slice recordings and the approximate entropy method to test this hypothesis. The approximate entropy (complexity) values of the hippocampal γ oscillations are estimated from the 14 hippocampal slices. Our results show that it takes at least 100 msec to see any hippocampal activities in response to the 100 Hz stimulus. These patterns noticeably changed after 100 msec until 300 msec after the stimulus Finally, they were less prominent after 300 msec. We have analyzed the isolated hippocampal γ oscillations (between 150 and 250 msec after the stimulus) using the approximate entropy (ApEn) method. Our results showed that the ApEn (complexity) values of hippocampal γ oscillations during nicotine exposure were reduced compared to those of hippocampal γ oscillations during control, and washout. This reduction was much more significant in response to acute nicotine exposure (p < 0.05) compared to those during control and washout conditions. These results suggest that the neural firing becomes regular and the hippocampal networks become synchronized in response to nicotine exposure.
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spelling pubmed-29123182010-07-30 Investigating the synchronization of hippocampal neural network in response to acute nicotine exposure Akkurt, David Akay, Yasemin M Akay, Metin J Neuroeng Rehabil Research Previous studies suggested that γ oscillations in the brain are associated with higher order cognitive function including selective visual attention, motor task planning, sensory perception, working memory and dreaming REM sleep. These oscillations are mainly observed in cortical regions and also occur in neocortical and subcortical areas and the hippocampus. In this paper, we investigate the influence of acute exposure to nicotine on the complexity of hippocampal γ oscillations. Using the approximate entropy method, the influence of acute nicotine exposure on the hippocampal γ oscillations was investigated. The hippocampal γ oscillations have been generated in response to the 100 Hz stimulus and isolated using the visual inspection and spectral analysis method. Our central hypothesis is that acute exposure to nicotine significantly reduces the complexity of hippocampal γ oscillations. We used brain-slice recordings and the approximate entropy method to test this hypothesis. The approximate entropy (complexity) values of the hippocampal γ oscillations are estimated from the 14 hippocampal slices. Our results show that it takes at least 100 msec to see any hippocampal activities in response to the 100 Hz stimulus. These patterns noticeably changed after 100 msec until 300 msec after the stimulus Finally, they were less prominent after 300 msec. We have analyzed the isolated hippocampal γ oscillations (between 150 and 250 msec after the stimulus) using the approximate entropy (ApEn) method. Our results showed that the ApEn (complexity) values of hippocampal γ oscillations during nicotine exposure were reduced compared to those of hippocampal γ oscillations during control, and washout. This reduction was much more significant in response to acute nicotine exposure (p < 0.05) compared to those during control and washout conditions. These results suggest that the neural firing becomes regular and the hippocampal networks become synchronized in response to nicotine exposure. BioMed Central 2010-07-13 /pmc/articles/PMC2912318/ /pubmed/20626893 http://dx.doi.org/10.1186/1743-0003-7-31 Text en Copyright ©2010 Akkurt et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Akkurt, David
Akay, Yasemin M
Akay, Metin
Investigating the synchronization of hippocampal neural network in response to acute nicotine exposure
title Investigating the synchronization of hippocampal neural network in response to acute nicotine exposure
title_full Investigating the synchronization of hippocampal neural network in response to acute nicotine exposure
title_fullStr Investigating the synchronization of hippocampal neural network in response to acute nicotine exposure
title_full_unstemmed Investigating the synchronization of hippocampal neural network in response to acute nicotine exposure
title_short Investigating the synchronization of hippocampal neural network in response to acute nicotine exposure
title_sort investigating the synchronization of hippocampal neural network in response to acute nicotine exposure
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912318/
https://www.ncbi.nlm.nih.gov/pubmed/20626893
http://dx.doi.org/10.1186/1743-0003-7-31
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