The Laforin–Malin Complex, Involved in Lafora Disease, Promotes the Incorporation of K63-linked Ubiquitin Chains into AMP-activated Protein Kinase β Subunits

Lafora progressive myoclonus epilepsy is a fatal neurodegenerative disorder caused by defects in the function of at least two proteins: laforin, a dual-specificity protein phosphatase, and malin, an E3-ubiquitin ligase. In this study, we report that a functional laforin–malin complex promotes the ub...

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Detalles Bibliográficos
Autores principales: Moreno, Daniel, Towler, Mhairi C., Hardie, D. Grahame, Knecht, Erwin, Sanz, Pascual
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912345/
https://www.ncbi.nlm.nih.gov/pubmed/20534808
http://dx.doi.org/10.1091/mbc.E10-03-0227

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