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Telomere-Mediated Chromosomal Instability Triggers TLR4 Induced Inflammation and Death in Mice

BACKGROUND: Telomeres are essential to maintain chromosomal stability. Cells derived from mice lacking telomerase RNA component (mTERC(−/−) mice) display elevated telomere-mediated chromosome instability. Age-dependent telomere shortening and associated chromosome instability reduce the capacity to...

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Detalles Bibliográficos
Autores principales:	Bhattacharjee, Rabindra N., Banerjee, Birendranath, Akira, Shizuo, Hande, M. Prakash
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912374/ https://www.ncbi.nlm.nih.gov/pubmed/20686699 http://dx.doi.org/10.1371/journal.pone.0011873

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