53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

Germ-line mutations in BRCA1 predispose to breast and ovarian cancer. BRCA1-mutated tumors show genomic instability, mainly as a consequence of impaired recombinatorial DNA repair. Here we identify 53BP1 as an essential factor for sustaining the growth arrest induced by Brca1 deletion. Depletion of...

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Detalles Bibliográficos
Autores principales: Bouwman, Peter, Aly, Amal, Escandell, Jose M., Pieterse, Mark, Bartkova, Jirina, van der Gulden, Hanneke, Hiddingh, Sanne, Thanasoula, Maria, Kulkarni, Atul, Yang, Qifeng, Haffty, Bruce G., Tommiska, Johanna, Blomqvist, Carl, Drapkin, Ronny, Adams, David J., Nevanlinna, Heli, Bartek, Jiri, Tarsounas, Madalena, Ganesan, Shridar, Jonkers, Jos
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912507/
https://www.ncbi.nlm.nih.gov/pubmed/20453858
http://dx.doi.org/10.1038/nsmb.1831

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