Widespread Antisense Transcription in Escherichia coli

The vast majority of annotated transcripts in bacteria are mRNAs. Here we identify ~1,000 antisense transcripts in the model bacterium Escherichia coli. We propose that these transcripts are generated by promiscuous transcription initiation within genes and that many of them regulate expression of t...

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Detalles Bibliográficos
Autores principales: Dornenburg, James E., DeVita, Anne M., Palumbo, Michael J., Wade, Joseph T.
Formato: Texto
Lenguaje:English
Publicado: American Society of Microbiology 2010
Materias:
Observation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912661/
https://www.ncbi.nlm.nih.gov/pubmed/20689751
http://dx.doi.org/10.1128/mBio.00024-10
Descripción
Sumario:The vast majority of annotated transcripts in bacteria are mRNAs. Here we identify ~1,000 antisense transcripts in the model bacterium Escherichia coli. We propose that these transcripts are generated by promiscuous transcription initiation within genes and that many of them regulate expression of the overlapping gene.

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