Widespread Antisense Transcription in Escherichia coli

The vast majority of annotated transcripts in bacteria are mRNAs. Here we identify ~1,000 antisense transcripts in the model bacterium Escherichia coli. We propose that these transcripts are generated by promiscuous transcription initiation within genes and that many of them regulate expression of t...

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Detalles Bibliográficos
Autores principales: Dornenburg, James E., DeVita, Anne M., Palumbo, Michael J., Wade, Joseph T.
Formato: Texto
Lenguaje:English
Publicado: American Society of Microbiology 2010
Materias:
Observation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912661/
https://www.ncbi.nlm.nih.gov/pubmed/20689751
http://dx.doi.org/10.1128/mBio.00024-10
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author Dornenburg, James E.
DeVita, Anne M.
Palumbo, Michael J.
Wade, Joseph T.
author_facet Dornenburg, James E.
DeVita, Anne M.
Palumbo, Michael J.
Wade, Joseph T.
author_sort Dornenburg, James E.
collection PubMed
description The vast majority of annotated transcripts in bacteria are mRNAs. Here we identify ~1,000 antisense transcripts in the model bacterium Escherichia coli. We propose that these transcripts are generated by promiscuous transcription initiation within genes and that many of them regulate expression of the overlapping gene.
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spelling pubmed-29126612010-08-04 Widespread Antisense Transcription in Escherichia coli Dornenburg, James E. DeVita, Anne M. Palumbo, Michael J. Wade, Joseph T. mBio Observation The vast majority of annotated transcripts in bacteria are mRNAs. Here we identify ~1,000 antisense transcripts in the model bacterium Escherichia coli. We propose that these transcripts are generated by promiscuous transcription initiation within genes and that many of them regulate expression of the overlapping gene. American Society of Microbiology 2010-05-18 /pmc/articles/PMC2912661/ /pubmed/20689751 http://dx.doi.org/10.1128/mBio.00024-10 Text en Copyright © 2010 Dornenburg et al. http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-nc-sa/3.0/) , which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Observation
Dornenburg, James E.
DeVita, Anne M.
Palumbo, Michael J.
Wade, Joseph T.
Widespread Antisense Transcription in Escherichia coli
title Widespread Antisense Transcription in Escherichia coli
title_full Widespread Antisense Transcription in Escherichia coli
title_fullStr Widespread Antisense Transcription in Escherichia coli
title_full_unstemmed Widespread Antisense Transcription in Escherichia coli
title_short Widespread Antisense Transcription in Escherichia coli
title_sort widespread antisense transcription in escherichia coli
topic Observation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912661/
https://www.ncbi.nlm.nih.gov/pubmed/20689751
http://dx.doi.org/10.1128/mBio.00024-10
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AT devitaannem widespreadantisensetranscriptioninescherichiacoli
AT palumbomichaelj widespreadantisensetranscriptioninescherichiacoli
AT wadejosepht widespreadantisensetranscriptioninescherichiacoli

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