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APP Intracellular Domain Impairs Adult Neurogenesis in Transgenic Mice by Inducing Neuroinflammation

BACKGROUND: A devastating aspect of Alzheimer's disease (AD) is the progressive deterioration of memory due to neuronal loss. Amyloid precursor protein (APP) occupies a central position in AD and APP-derived amyloid-β (Aβ) peptides are thought to play a pivotal role in disease pathogenesis. Non...

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Detalles Bibliográficos
Autores principales:	Ghosal, Kaushik, Stathopoulos, Andrea, Pimplikar, Sanjay W.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912762/ https://www.ncbi.nlm.nih.gov/pubmed/20689579 http://dx.doi.org/10.1371/journal.pone.0011866

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