Parkin Is Protective against Proteotoxic Stress in a Transgenic Zebrafish Model

BACKGROUND: Mutations in the gene encoding the E3 ubiquitin ligase parkin (PARK2) are responsible for the majority of autosomal recessive parkinsonism. Similarly to other knockout mouse models of PD-associated genes, parkin knockout mice do not show a substantial neuropathological or behavioral phen...

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Detalles Bibliográficos
Autores principales: Fett, Mareike E., Pilsl, Anna, Paquet, Dominik, van Bebber, Frauke, Haass, Christian, Tatzelt, Jörg, Schmid, Bettina, Winklhofer, Konstanze F.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912770/
https://www.ncbi.nlm.nih.gov/pubmed/20689587
http://dx.doi.org/10.1371/journal.pone.0011783

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