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Folding of Matrix Metalloproteinase-2 Prevents Endogenous Generation of MHC Class-I Restricted Epitope
BACKGROUND: We previously demonstrated that the matrix metalloproteinase-2 (MMP-2) contained an antigenic peptide recognized by a CD8 T cell clone in the HLA-A*0201 context. The presentation of this peptide on class I molecules by human melanoma cells required a cross-presentation mechanism. Surpris...
Autores principales: | Renaud, Virginie, Godefroy, Emmanuelle, Larrieu, Pierre, Fleury, Fabrice, Jotereau, Francine, Guilloux, Yannick |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912773/ https://www.ncbi.nlm.nih.gov/pubmed/20689590 http://dx.doi.org/10.1371/journal.pone.0011894 |
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