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Folding of Matrix Metalloproteinase-2 Prevents Endogenous Generation of MHC Class-I Restricted Epitope

BACKGROUND: We previously demonstrated that the matrix metalloproteinase-2 (MMP-2) contained an antigenic peptide recognized by a CD8 T cell clone in the HLA-A*0201 context. The presentation of this peptide on class I molecules by human melanoma cells required a cross-presentation mechanism. Surpris...

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Detalles Bibliográficos
Autores principales:	Renaud, Virginie, Godefroy, Emmanuelle, Larrieu, Pierre, Fleury, Fabrice, Jotereau, Francine, Guilloux, Yannick
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912773/ https://www.ncbi.nlm.nih.gov/pubmed/20689590 http://dx.doi.org/10.1371/journal.pone.0011894

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